Mony J. de Leon Ed.D.

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We evaluated three groups of elderly individuals who were carefully screened to rule out clinically significant diseases that could affect cognition. They were matched for age and education. The groups included normals (N=18), Alzheimer's Disease (AD) patients (N=15), and minimally impaired individuals with memory complaints and impairments but who did not(More)
While many neuropsychological studies have demonstrated age-related performance alterations in tests thought to reflect frontal and temporal lobe function, there is little direct observation and comparison of these hypothesized brain changesin vivo. The cerebral glucose metabolism of frontal, temporal, and cerebellar regions was examined in 40 young ((More)
The volume of temporal lobe structures was examined in twenty-seven older (mean age of 69.2±8.3 years) and ten younger subjects (mean age of 26.1±4.1 years) using quantitative magnetic resonance imaging (MRI) methods. Multiple regression analysis, using gender, overall atrophy, and head size as covariates, showed unique contributions of age to variance in(More)
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