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Antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, including phencyclidine (PCP) and ketamine, protect against brain damage in neurological disorders such as stroke. However, these agents have psychotomimetic properties in humans and morphologically damage neurons in the cerebral cortex of rats. It is now shown that the(More)
The receptor mGluR5 is a metabotropic glutamate receptor with messenger RNA abundantly present throughout cortex, hippocampus, and caudate/putamen that is also coupled to phosphatidyl inositide hydrolysis and calcium mobilization. In this study, the distribution of mGluR5 was examined in rat brain by immunocytochemistry. The antibody utilized is highly(More)
1. This paper represents a continuation of our effort to examine the relationship between the physiology of distinct classes of primate lateral geniculate nucleus (LGN) cells and spatial vision. The present study focuses on modeling the contrast-sensitivity functions (CSFs) of separate LGN cell classes, examining differences in the CSFs of different classes(More)
Glutamate has an important neuromodulatory role in synaptic transmission through metabotropic glutamate receptors (mGluRs) linked to a variety of G-protein-coupled second messenger pathways. Activation of these receptors on relay cells in the lateral geniculate nucleus (LGN) with the agonist trans-(1S,3R)-1-amino-1, 3-cyclopentanedicarboxylic acid produces(More)
Microelectrode mapping methods and anatomical procedures were combined in the same animals to reveal the cortical connections of three architectonically distinct representations of the body surface in the somatosensory cortex of grey squirrels. In individual experiments, microelectrode multiunit recordings were used to determine the somatotopic organization(More)
Recent anatomical studies have suggested that the cells located in the interlaminar zones (ILZs) of the primate dorsal lateral geniculate nucleus (LGN) relay visual information from the retina to the striate cortex in a manner similar to that of W-cells in the LGN of cat. In the present study, we examined this idea directly by recording the response(More)
In order to better understand the organization of extrastriate cortex in tree shrews, injections in area 17 of wheat germ agglutinin or tritiated proline were used to reveal an intrinsic pattern of connections, ipsilateral connections with area 18 and two other subdivisions of cortex, and callosal connections with areas 17 and 18 of the opposite cerebral(More)
Much confusion has arisen recently over the question of whether excitotoxic neuronal degeneration can be considered an apoptotic phenomenon. Here, we addressed this question by using ultrastructural methods and DNA fragmentation analysis to compare a prototypic apoptotic in vivo central nervous system cell death process (physiologic cell death in the(More)
Phencyclidine and other antagonists of the N-methyl-D-aspartate subtype of glutamate receptor cause psychosis in humans. In low doses these agents induce a reversible neurotoxic reaction in the rat brain that is limited to the retrosplenial granular cortex. Some investigators have reported that phencyclidine at higher doses or by more prolonged treatment(More)
In order to analyze the arborization pattern of single axons innervating layer IV of striate cortex in Galago (a prosimian primate), injections of horseradish peroxidase were made into the white matter below visual cortex. Two distinct fiber types were identified which ramify within different subdivisions of layer IV. Fibers with large axons (type I) have(More)