BACKGROUND Lymphoma is the leading cause of cancer-related death among HIV-infected patients in the antiretroviral therapy (ART) era. METHODS We studied lymphoma patients in the Centers for AIDS Research Network of Integrated Clinical Systems from 1996 until 2010. We examined differences stratified by histology and diagnosis year. Mortality and predictors… (More)
BACKGROUND Lymphoma incidence is increased among human immunodeficiency virus (HIV)-infected individuals soon after antiretroviral therapy (ART), perhaps due to unmasking immune reconstitution inflammatory syndrome (IRIS). Clinical characteristics and survival for unmasking lymphoma IRIS have not been described. METHODS We studied lymphoma patients in the… (More)
Tobacco use, infection with HIV and active tuberculosis (TB) are important public health problems worldwide. Smoking affects susceptibility to TB, with an increased risk of infection, TB disease and TB death [1, 2]. An estimated 1.1 million of the 8.6 million people who developed TB in 2012 were HIV-positive . It has been estimated that smoking could… (More)
Among patients with tuberculosis and human immunodeficiency virus type 1, CD4-stratified initiation of antiretroviral therapy (ART) is recommended, with earlier ART in those with low CD4 counts. However, the impact of implementation fidelity to this recommendation is unknown. We examined a prospective cohort study of 395 adult patients diagnosed with… (More)
OBJECTIVE We aimed to perform a systematic review and meta-analysis examining the impact of TB treatment at the time of combination antiretroviral therapy (cART) initiation on subsequent mortality. METHODS We searched PubMed, EMBASE, and selected conference proceedings for studies that report adult mortality on cART, stratified by TB treatment status at… (More)
Persons who died of Ebola virus disease at home in rural communities in Liberia and Guinea resulted in more secondary infections than persons admitted to Ebola treatment units. Intensified monitoring of contacts of persons who died of this disease in the community is an evidence-based approach to reduce virus transmission in rural communities.
an emergency syringe exchange program (SEP) was implemented in response to an unprecedented HIV outbreak linked to injection drug use in a small rural Indiana community. To assess impact of the SEP, we compared injection-related risk behaviors reported over time. Methods. At each SEP visit, clients received sterile syringes, a wound kit, harm reduction… (More)
In 2012, the World Health Organization recommended that HIV-infected patients starting tuberculosis (TB) treatment be initiated on antiretroviral therapy (ART) after 8 weeks if CD4 count ≥50 cells/mm3 and after 2 weeks if CD4 count <50 cells/mm3. Examination of this type of CD4-stratified ART timing strategy would be useful to inform development and… (More)