Monique L. Den Boer

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BACKGROUND MicroRNA regulate the activity of protein-coding genes including those involved in hematopoietic cancers. The aim of the current study was to explore which microRNA are unique for seven different subtypes of pediatric acute lymphoblastic leukemia. DESIGN AND METHODS Expression levels of 397 microRNA (including novel microRNA) were measured by(More)
Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify 89 putative Fbw7 substrates, including several(More)
We investigated the effects of targeting the mitotic regulators aurora kinase A and B in pediatric acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Aurora protein expression levels in pediatric ALL and AML patient samples were determined by western blot and reverse phase protein array. Both kinases were overexpressed in ALL and AML(More)
Both tumour suppressor and oncogenic functions have been ascribed to the atypical zeta isoform of protein kinase C (PKCζ), whereas its constitutively active form PKMζ is almost exclusively expressed in the brain where it has a role in long-term memory. Using primers unique for either isoform, we found that both PKCζ and PKMζ were expressed in a subset of(More)
(4217 articles) Neoplasia (149 articles) Genomics (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: digital object identifier (DOIs) and date of initial publication. the indexed by PubMed from initial publication. Citations to(More)
leukemia clinical response l-asparaginase in pediatric acute lymphoblastic Up-regulation of asparagine synthetase expression is not linked to the Updated information and services can be found at: (4217 articles) Neoplasia (1086 articles) Gene Expression (3667 articles) Clinical Trials and Observations Articles on similar topics can be found in the following(More)
ALL promoter usage is not linked to glucocorticoid resistance in childhood Glucocorticoid-induced glucocorticoid-receptor expression and Updated information and services can be found at: (4217 articles) Neoplasia (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections
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