Monique Chalansonnet

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We investigated in adult rats whether a relatively short exposure to a novel odour can lead to changes in reactivity of olfactory bulb principal neurons. Naive rats were exposed to isoamyl acetate for 20 min per day either for 6 consecutive days or for a single 20-min exposure. Control group was non-exposed. Under anaesthesia, responsiveness of each(More)
The mechanisms of action involved in the neurotoxicity of solvents are poorly understood. In vitro studies have suggested that the effects of some solvents might be due to the formation of reactive oxygen species (ROS). This study assesses hydroxyl radical (OH) generation and measures malondialdehyde (MDA) levels in the cerebral tissue of rats exposed to(More)
This study compares the single-unit responses of 74 mitral/tufted cells recorded in freely breathing rats to step increases of the intensity of five odorants from 2 x 10(-4) to 10(-1) of saturated vapor pressure. It reveals a stability of the responses of these olfactory bulb output cells. Olfactory stimulation has frequently been shown to produce a strong(More)
The aim of this report is to expose several improvements which are essential for obtaining good recordings from the basal side of the olfactory mucosa of awake rats with Ag-AgCl electrodes implanted through holes drilled in the roof of the nasal bone. In a first step, we present how this minimally invasive method was developed and validated in anesthetized(More)
The olfactory bulb responses to odours display evident temporal organization, both in the form of high-frequency oscillations and precisely replicating triplets of spikes. In this study, the frequency of replicating triplets in a sample of 118 individual responses from 45 cells was compared with that in simulations of non-homogeneous Poisson processes,(More)
Notwithstanding increasing knowledge of titanium dioxide nanoparticles (TiO2 NPs) passing through biological barriers, their biodistribution to the central nervous system (CNS) and potential effects on blood-brain barrier (BBB) physiology remain poorly characterized. Here, we report time-related responses from single-dose intravenous (IV) administration of(More)
At present, there is controversy over the neurotoxic potential of styrene. Several epidemiological and clinical studies have shown that styrene exposure causes alterations of central nervous system functions in humans. Neurotransmitters have been implicated in the pathogenesis of styrene neurotoxicity in rodents. Several studies carried out on postmortem(More)
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