TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells… (More)
OBJECTIVE
There is substantial evidence supporting the role of interferon (IFN)-gamma-producing T helper (T(H)) 1 and interleukin (IL)-17-expressing T(H)17 lymphocytes in multiple sclerosis (MS) and… (More)
The blood-brain barrier (BBB) is composed of tightly bound endothelial cells (ECs) and perivascular astrocytes that regulate central nervous system (CNS) homeostasis. We showed that astrocytes… (More)
The blood-brain barrier (BBB) restricts molecular and cellular trafficking between the blood and the CNS. Although astrocytes are known to control BBB permeability, the molecular determinants of this… (More)
An important determinant of sensitivity to ischaemia is altered ion homeostasis, especially disturbances in intracellular Na+ $${\left( {Na^{ + }_{i} } \right)}$$ handling. As no study has so far… (More)
Trafficking of antigen-presenting cells into the CNS is essential for lymphocyte reactivation within the CNS compartment. Although perivascular dendritic cells found in inflammatory lesions are… (More)
OBJECTIVE
Dysregulation of the blood-brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system changes partaking in lesion formation in both… (More)
Genetically modified mouse models of many human diseases reflecting cardiovascular alterations are currently available. To date, little information on absolute myocardial perfusion in mice is found… (More)
and Magnetosomes in Bacteria, D. Schüler, Ed. (Springer-Verlag, Berlin Heidelberg, 2007), pp. 25–36. 16. Materials and methods are available as supporting material on Science Online. 17. D. Schüler,… (More)