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Determination of Piroxicam and Degradation Products in Drugs by TLC
A thin-layer chromatography method with densitometric detection for the determination of piroxicam and its degradation products is described. Separation was on silica gel TLC plates with ethylExpand
Analysis of Nefopam by TLC-densitometry. A Study of Degradation Mechanism in Solutions Under Stress Conditions.
A new, simple, selective, precise and accurate thin-layer chromatographic method for quantification of nefopam hydrochloride in formulations has been established and validated. TLC F254 silica gelExpand
Hydrolysis of 2,4-dithiophenobarbital.
Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2-12 was investigated at 40 and 60 degrees C using UV spectrophotometry. The values of reaction order, rate constants, pKa1 and pKa2Expand
The Stability Study of a Novel Phenylpiperazine Derivative
N-phenylpiperazine compounds are a very large class of chemicals, and some of them have the ability to cross the blood-brain barrier due to the small size and the lipohilic nature. This group ofExpand
Stability of 2-thiophenobarbital and its N-methyl derivatives in the presence of beta-cyclodextrin.
The rates of hydrolysis of thiophenobarbital and its N-mono- and N,N'-dimethyl-derivatives were determined under different conditions of pH and temperature using UV spectroscopy. They were comparedExpand
Hydrolysis of N,N- and N,S-dimethyl derivatives of 2-thiophenobarbital.
Kinetics of hydrolysis of N,N- and N,S-dimethyl-2-thiophenobarbital and products of this reaction were investigated. The UV spectroscopy served as a tool for kinetic investigations and chromatographyExpand
Kinetics of Hydrolysis of N-Methyl-2,4-dithiophenobarbital
The rate of hydrolytic degradation of N-methyl-2,4-dithiophenobarbital by spectrophotometric and separation methods was studied. The rate constants, order of reaction, activation energy, and pKaExpand
Hydrolysis of N- and S-monomethyl derivatives of 2-thiophenobarbital.
Kinetics of hydrolysis of S-methyl-2-thiophenobarbital in aqueous solutions was investigated using the UV spectroscopic method within the pH range 1.5-12.9 at 60 degrees C. Chromatography was used toExpand
TLC-Densitometric Determination of Tenoxicam and Its Degradation Products in Pharmaceutical Preparations and after Hydrolysis in Solutions
A direct, rapid, and sensitive thin-layer chromatography (TLC) method with densitometric detection was developed and validated for the determination of tenoxicam and its degradation products. TheExpand
TLC-Densitometric Method for Quantification of Oxaprozin and its Degradation Products in Pharmaceutical Preparations
A new, simple and rapid thin-layer chromatographic method with densitometric detection has been developed and validated for analysis of oxaprozin and its degradation products. Chromatography wasExpand