Monika Majewska

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The aim of the study was an evaluation of changes in protein level and activity of SOD isoenzymes, and the participation of AP-1 and NF-kappaB in subsequent stages of colorectal cancer development. Studies were conducted on 65 colorectal cancers. Controls were unchanged colon regions. Activity of SOD isoenzymes, lipid peroxidation level (TBARS), and protein(More)
Many helminths cause long-lasting infections, living for several years in mammalian hosts reflecting a well balanced coexistence between host and parasite. There are many possible explanations as to how they can survive for lengthy periods. One possibility is their antioxidant systems, which can serve as defence mechanisms against host-generated oxygen(More)
In recent years, there is an increasing interest in antioxidants. The main reason for this interest is the protection of cells, their organelles (especially membranes) and metabolic pathways against oxygen free radicals and their reactive derivatives (ROS). They participate in formation of chronic inflammation states and other diseases associated with(More)
Impairments of antioxidant enzyme expression are often concomitant with the onset of cancer. Due to epigenetic factors causing an inflammatory state the gastrointestinal tract can become exposed to reactive oxygen species. The purpose of our work was to evaluate mRNA and protein levels of superoxide dismutase isoenzymes in human colorectal adenocarcinoma(More)
The aim of the present paper was to describe the enzymatic antioxidant system in Hymenolepis diminuta collected from rats exposed to chronic cestode invasion. We dissected different tissues of H. diminuta (immature proglottids, genital primordia, hermaphroditic proglottids, early uterus, and gravid uterus) and studied activity of: superoxide dismutases(More)
INTRODUCTION Since one of the many proposed factors in the pathogenesis of acute and chronic pancreatitis is oxidative stress, the aim of the research was evaluation of antioxidant defense mechanisms, with particular emphasis on the role of reduced glutathione and GSH-dependent enzymes. MATERIAL AND METHODS The study involved a group of 35 patients with(More)
UNLABELLED Oxygen free radicals and their reactive derivatives participate in formation of chronic inflammation states, which facilitate development of gastrointestinal tract tumors. Oxidative stress is one of the main causes of damage to cell membranes in result of exacerbated lipid peroxidation process. End products of lipid peroxidation (aldehydes,(More)
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