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- Publications
- Influence
Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery
- Monika Kopečná, Miloslav Machacek, +4 authors K. Vávrová
- Chemistry, Medicine
- Pharmaceutical Research
- 29 June 2017
PurposeTo study new skin penetration/permeation enhancers based on amphiphilic galactose derivatives.MethodsTwo series of alkyl and alkenyl galactosides were synthesized and evaluated for their… Expand
Transdermal Delivery and Cutaneous Targeting of Antivirals using a Penetration Enhancer and Lysolipid Prodrugs
- Denisa Diblíková, Monika Kopečná, +4 authors K. Vávrová
- Medicine
- Pharmaceutical Research
- 1 April 2014
PurposeIn this work, we investigate prodrug and enhancer approaches for transdermal and topical delivery of antiviral drugs belonging to the 2,6-diaminopurine acyclic nucleoside phosphonate (ANP)… Expand
Dodecyl Amino Glucoside Enhances Transdermal and Topical Drug Delivery via Reversible Interaction with Skin Barrier Lipids
- Monika Kopečná, Miloslav Machacek, +4 authors K. Vávrová
- Chemistry, Medicine
- Pharmaceutical Research
- 9 January 2017
PurposeSkin permeation/penetration enhancers are substances that enable drug delivery through or into the skin.MethodsTo search for new enhancers with high but reversible activity and acceptable… Expand
Permeability and microstructure of cholesterol-depleted skin lipid membranes and human stratum corneum.
- M. Sochorová, Pavla Audrlická, +5 authors K. Vávrová
- Chemistry, Medicine
- Journal of colloid and interface science
- 1 February 2019
Cholesterol (Chol) is one of the major skin barrier lipids. The physiological level of Chol in the stratum corneum (SC) appears to exceed its miscibility with other barrier lipids, as some Chol is… Expand
Permeation enhancers in transdermal drug delivery: benefits and limitations
- A. Kováčik, Monika Kopečná, K. Vávrová
- Medicine
- Expert opinion on drug delivery
- 7 January 2020
ABSTRACT Introduction: Transdermal drug delivery has several clinical benefits over conventional routes of drug administration. To open the transdermal route for a wider range of drugs, including… Expand
Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers
- Monika Kopečná, Miloslav Machacek, Anna Nováčková, Georgios Paraskevopoulos, Jaroslav Roh, K. Vávrová
- Chemistry, Medicine
- Scientific Reports
- 10 October 2019
Skin penetration/permeation enhancers are compounds that improve (trans)dermal drug delivery. We designed hybrid terpene-amino acid enhancers by conjugating natural terpenes (citronellol, geraniol,… Expand
Fluorescent Penetration Enhancers Reveal Complex Interactions among the Enhancer, Drug, Solvent, and Skin.
- Monika Kopečná, A. Kováčik, +4 authors K. Vávrová
- Chemistry, Medicine
- Molecular pharmaceutics
- 10 January 2019
Skin penetration/permeation enhancers facilitate drug delivery through the skin barrier. However, the specific mechanisms that govern the enhancer interactions with the skin, drug, and donor solvent… Expand
SAMPA: A free software tool for skin and membrane permeation data analysis.
- A. Bezrouk, Z. Fiala, L. Kotingová, I. Krulichová, Monika Kopečná, K. Vávrová
- Materials Science, Medicine
- Toxicology in vitro : an international journal…
- 1 October 2017
Skin and membrane permeation experiments comprise an important step in the development of a transdermal or topical formulation or toxicological risk assessment. The standard method for analyzing… Expand
Sociální marketing jako nástroj získávání dobrovolníků v sociálních službách
- Monika Kopečná
- Sociology
- 23 January 2015
The major objective of this study is to explore the methods social services use to acquire volunteers. This thesis concerns the problem of recruiting volunteers for social services. The theory… Expand