Monika Kapoor

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OBJECTIVES Amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer's disease (AD), but soluble oligomeric Aβ is considered to be more potent and has been hypothesized to directly impair learning and memory. Also, evidences from some clinical studies indicated that Aβ oligomer formation is the major cause for early(More)
Parkinson's disease (PD), is an age-related, progressive neurodegenerative disorder that affects movement and is characterized by the loss of dopaminergic neurons in the nigrostriatal region. Although the clinical and pathological features of PD are complex, recent studies have indicated that microglial NADPH oxidase play a key role in its pathology. A(More)
In many kinds of equipment, it is important to produce readily control accurate waveforms of various frequencies and profiles such as agile frequency sources with low phase noise and low spurious signal content for communications, and simply generated frequency for industrial and biomedical applications. A direct digital synthesizer (DDS) provides many(More)
Due to high complexity of VLSI systems used in various applications power dissipation becomes a limiting factor in VLSI circuits and systems, which arises from its switching activity influenced by the supply voltage and effective capacitance. Charging and discharging of the node capacitances in CMOS circuits creates power dissipation called as dynamic power(More)
Power consumption is hurdle problem face by nanometer CMOS circuit in deep submicron process (DSM) technology. As technology scales down, leakage power significantly increases very rapidly due to high transistor density, reduced voltage and oxide thickness. A new circuit technique based on: “Sleep Switch” is proposed in this paper for reducing the(More)
Blockage along with sudden restoration of blood following ischemia, results in several cascading events, such as a massive ROS production which plays an important role in the pathophysiology of ischemia. NADPH oxidase complex in mitochondria complex is believed to be the major source for ROS production. The present study explores the therapeutic potential(More)
An effort is made to minimize the arithmetic intricacy of signal by using the VHDL module on FPGA. A curve fitting algorithm is used for finding the fundamental frequency of a given signal. Modification of algorithm is reducing the arithmetic complex-city become extinct the cubic solution. This is mature a fast approach for the signal processing and reduced(More)
In telecommunications, direct-sequence spread spectrum (DSSS) is a modulation technique. As with other spread spectrum technologies, the transmitted signal takes up more bandwidth than the information signal that modulates the carrier or broadcast frequency. DS-CDMA is advantageous for ad hoc networks because it eliminates the need for any frequency or(More)