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eIF5 is the GTPase activating protein (GAP) for the eIF2 · GTP · Met-tRNAi (Met) ternary complex with a critical role in initiation codon selection. Previous work suggested that the eIF5 mutation G31R/SUI5 elevates initiation at UUG codons by increasing GAP function. Subsequent work implicated eIF5 in rearrangement of the preinitiation complex (PIC) from an(More)
AIMS Cells possess multiple methods for counteracting the deleterious consequences of stress induced by physical and chemical stimuli. Heat stress causes variations in the cellular environment, leading to cellular morbidity or mortality. Natural compounds that contain phenolic antioxidants, offer various therapeutic and biological activities. Vitexin, a(More)
Apoptosis and autophagy are genetically regulated, evolutionarily conserved processes that can jointly seal cancer cell fates, and numerous death stimuli are capable of activating either pathway. Although crosstalk between apoptosis and autophagy is quite complex and sometimes contradictory, it remains a key factor determining the outcomes of death-related(More)
Gender classification from fingerprints is an important step in forensic anthropology in order to identify the gender of a criminal and minimize the list of suspects search. The objective of the present study was to study the differences in the finger loop ridge count among male and female subjects. ANOVA analysis revealed no significant mean difference in(More)
Aflatoxin B1 (AFB1) is the most toxic aflatoxin species and has been shown to be associated with specific as well as non-specific immune responses. In the present study, using murine macrophage Raw 264.7 cells as a model, we report that short exposure (6h) to AFB1 caused an increase in the cellular calcium pool in mitochondria, which in turn elevated(More)
OBJECTIVE To examine the individual and synergistic anti-listerial effect of nisin and leaf essential oil of Metasequoia glyptostroboides (M. glyptostroboides) against one of the leading foodborne pathogens Listeria monocytogenes (L. monocytogenes) ATCC 19116 in milk samples. METHODS The whole (8%), low (1%) and skim (no fat content) milk samples were(More)
— This paper presents the new design of a simple pulse width modulator. The circuit principle is based on uniform sampling method known as uniform sampling PWM signal (UPWM) with a current comparator. The proposed scheme is simpler than the existing PWM methods and the duty factor linearly depend upon modulating signal. Another advantage is that the circuit(More)
Although quercetin is very well known for its anticancer activity, however it shows some drawbacks. Herein, we have evaluated the apoptotic effect TEF (5, 3'-dihydroxy-3, 7, 4'-triethoxyflavone), a newly synthesized quercetin derivative on HCT-116 colon cancer cells. After 24h of treatment, the proliferation of colon cancer cells was inhibited by TEF. TEF(More)
Plant-derived compounds are an important source of clinically useful anti-cancer agents. Chrysin, a biologically active flavone found in many plants, has limited usage for cancer chemotherapeutics due to its poor oral bioavailability. 5-Hydroxy-7-methoxyflavone (HMF), an active natural chrysin derivative found in various plant sources, is known to modulate(More)
—This paper presents a 0.35µm CMOS frequency to voltage converter for portable applications which is based on a operating principle comprises a differentiator, voltage to current converter, two RMS-DC converters, and a divider. Results show that the converter has a power consumption of 11.89mW operating at 3.3V supply voltage. This converter can accurately(More)