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Basic indicators of calcium and bone metabolism and the calcium tolerance test were investigated in patients with untreated hyperthyroidism, Hashimoto's thyroiditis, after total thyroidectomy and in controls. In florid hyperthyroidism elevated values of indicators of bone new formation (osteocalcin and bone fraction of alkaline phosphatases) and of bone(More)
  • M Adam, Z Deyl
  • 1983
Immunofluorescence studies have shown the presence of collagen type III in addition to types I and II in osteoarthrotic cartilage. The presence of collagen type III was verified biochemically: collagen was isolated and purified from the pronase digest of osteoarthrotic cartilage. Mixtures of different collagen types were fractionated first by two different(More)
BACKGROUND Calcitonin has an important role in the treatment of post-menopausal osteoporosis. The authors investigated the effect of calcitonin administration or calcitonin administration supplement with a diet rich in collagen proteins on markers of bone metabolism. METHODS AND RESULTS A group of 108 patients with postmenopausal osteoporosis (BMD lower(More)
The content of gamma-carboxyglutamic acid (gla) was determined in rat femoral bone and kidney cortex in rachitic and vitamin D treated animals. It was demonstrated that the level of gla is decreased in vitamin D depleted animals both in kidney cortex and femoral bone. Supplementation of vitamin D deprived animals with this vitamin resulted in an increase in(More)
BACKGROUND Tumor-derived tissue factor (TF) activates coagulation in vitro and in vivo in an orthotopic model of human pancreatic cancer. Here, we further characterized tumor-derived TF in this model. METHODS Conditioned medium (CM) of L3.6pl human pancreatic tumor cells and plasma from nude mice bearing L3.6pl tumors were ultracentrifuged, and the(More)
Two fluorescent fractions were found in total acid hydrolysate of elastin. The fraction with higher chromatography mobility in isopropyl alcohol/conc. ammonia/water (9 : 1 : 2) was purified by multiple preparative paper chromatography in the same solvent system, and by gel chromatography on Sephadex G-25, ion-exchange chromatography on phosphocellulose and(More)