Monika Šupová

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Hydroxyapatite (HA) is considered to be a bioactive material that favorably influences the adhesion, growth, and osteogenic differentiation of osteoblasts. To optimize the cell response on the hydroxyapatite composite, it is desirable to assess the optimum concentration and also the optimum particle size. The aim of our study was to prepare composite(More)
This review summarizes recent work on isolating and preparing bioapatites from various natural sources. First, the physicochemical properties of bioapatites are described and discussed. Then, a general summary of natural (animals and vegetals) sources for bioapatite production from various environments (terrestrial and water) is made. Special attention is(More)
Nanocomposite scaffolds which aimed to imitate a bone extracellular matrix were prepared for bone surgery applications. The scaffolds consisted of polylactide electrospun nano/sub-micron fibres, a natural collagen matrix supplemented with sodium hyaluronate and natural calcium phosphate nano-particles (bioapatite). The mechanical properties of the scaffolds(More)
Infections of the musculoskeletal system present a serious problem with regard to the field of orthopedic and trauma medicine. The aim of the experiment described in this study was to develop a resorbable nanostructured composite layer with the controlled elution of antibiotics. The layer is composed of collagen, hydroxyapatite nanoparticles, and vancomycin(More)
This review summarizes recent work on manufacturing biocomposites suitable for bone tissue engineering. There is a great need to engineer multi-phase (i.e. composite) materials that combine the advantages exhibited by each component of the material, with a structure and composition similar to that of natural bone. The discussion concentrates on the(More)
The aim of this study was to develop an osteo-inductive resorbable layer allowing the controlled elution of antibiotics to be used as a bone/implant bioactive interface particularly in the case of prosthetic joint infections, or as a preventative procedure with respect to primary joint replacement at a potentially infected site. An evaluation was performed(More)
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