Monica Thornton

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Peripheral blood mononuclear cells from male homosexuals with acquired immune deficiency syndrome (AIDS) and with AIDS related complex (ARC) were examined for the autologous mixed lymphocyte reaction (AMLR) between responder T and irradiated autologous non-T cells and in vitro influence of purified human interleukin-1 (IL-1) and -2 (IL-2) on the AMLR. The(More)
OBJECTIVE To determine the safety and efficacy of the sulphated polysaccharide, dextrin 2-sulphate, when delivered to the lymphatic circulation by the peritoneal route. DESIGN An open Phase I/II dose-escalation clinical study in which six patients with AIDS were treated with seven courses of dextrin 2-sulphate each lasting 1 month. METHODS During each(More)
Delivery of the sulfated polysaccharide dextrin 2-sulfate by the intraperitoneal route to the lymphatic circulation resulted in a clinically significant improvement in Kaposi's sarcoma in three patients. Our in vitro studies show that although sulfated dextrins do not interfere with the growth of isolated human umbilical vein endothelial cells, they do(More)
The use of phase-type distributions is an established method for extending the representational power of continuous time Bayesian networks beyond exponentially-distributed state transitions. In this paper, we propose a method for learning phase-type distributions from known parametric distributions. We find that by using particle swarm optimization to(More)
Probabilistic graphical models are widely used in the context of fault diagnostics and prognostics, providing a framework to model the relationships between faults and tests in complex systems. Bayesian networks have sufficient representational power as a model for system-level diagnosis but are inadequate for domains involving prognosis. In order to(More)