Monica Schliemann

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Apoptosis is a form of programmed cell death essential for the maintenance of homeostasis and the removal of potentially damaged cells in multicellular organisms. By binding its cognate membrane receptor, TNF receptor type 1 (TNF-R1), the proinflammatory cytokine Tumor Necrosis Factor (TNF) activates pro-apoptotic signaling via caspase activation, but at(More)
This work describes proand anti-apoptotic signal transduction pathways in a linked mathematical model. It emphasises the modelling and influence of the receptor from which those signal transduction pathways originate as well as the interaction of specific molecules within those signal cascades. The main focus of this work is the development and verification(More)
* Correspondence: E.Bullinger@ulg. Department of Electrical Engineering and Computer Science (Montefiore Institute) and GIGA (Interdisciplinary Cluster for Applied Geno-proteomics), Université de Liège, Belgium • Bioinformatics for Systems Biology by S. Krawetz (Ed.), Springer, February 2009 (2 ed.) ISBN: 978-1-934115-02-2 (BSB) • Systems Biology and(More)
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