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BACKGROUND Apoptosis is a form of programmed cell death essential for the maintenance of homeostasis and the removal of potentially damaged cells in multicellular organisms. By binding its cognate membrane receptor, TNF receptor type 1 (TNF-R1), the proinflammatory cytokine Tumor Necrosis Factor (TNF) activates pro-apoptotic signaling via caspase(More)
(BN) Systems biology is a holistic approach combining experimental data on multiple levels, from the genome and proteome over the interactome to signalling and metabolism in single cells, organs and organisms with the use of computational methods and predictive mathematical models. Bioinformatics is the application of computer science to biological systems,(More)
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