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Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often influenced by a wide array of experimental variables making it difficult to compare the results across the(More)
The formal extension of the conventional theory of dynamic programming to control problems with slow growth and a state constraint x 2 encounters two major drawbacks: on one hand the formal Hamiltonian may happen to be discontinuous; on the other hand, just as in the case of bounded controls, the imposition of a state constraint possibly gives rise to a(More)
OBJECTIVE The purpose of this study was to determine impact of needle gauge, type, and orientation on average volume of drop dispensed. PROCEDURE Five needle gauges (22G, 23G, 25G, 27G, and 30G) were examined. For each gauge, volume of drop delivered was determined for standard sharp beveled tip, blunt tip, and after breaking off of the sharp needle from(More)
PURPOSE Intravitreal murine lineage-negative bone marrow (BM) hematopoietic cells slow down retinal degeneration. Because human BM CD34+ hematopoietic cells are not precisely comparable to murine cells, this study examined the effect of intravitreal human BM CD34+ cells on the degenerating retina using a murine model. METHODS C3H/HeJrd1/rd1 mice,(More)
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