Monica Melegari

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A variety of natural and synthetic compounds are known to selfassemble to give transmembrane ion channels.1 Hydrogen-bonded macrocycles that can π-stack are a new type of channel motif.2 Thus, folate quartets stack to give ion channels in lipid bilayers.3 This folate assembly had a single-channel conductance of 10-20 picosiemens (pS), values consistent with(More)
A Si(100) surface featuring molecular recognition properties was obtained by covalent functionalization with a tetraphosphonate cavitand (Tiiii), able to complex positively charged species. Tiiii cavitand was grafted onto the Si by photochemical hydrosilylation together with 1-octene as a spatial spectator. The recognition properties of the Si-Tiiii surface(More)
Phosphonate cavitands are an emerging class of synthetic receptors for supramolecular sensing. The molecular recognition properties of the third-generation tetraphosphonate cavitands toward alcohols and water at the gas-solid interface have been evaluated by means of three complementary techniques and compared to those of the parent mono- and diphosphonate(More)
Guest-switchable crystals: A solid-state guest exchange of the tetraphosphonate cavitand Tiiii[H,CH(3),Ph] as host promotes single-crystal-to-single-crystal transformations (see graphic). The strong preference for methanol over water is observed in all three phases (gas, liquid, solid), thus demonstrating the fundamental role played by the preorganized(More)
The reactivity of CO(2) with polyamino substrates based on calix[4]arenes and on a difunctional, noncyclic model has been studied. All the compounds react with CO(2) in chloroform to form ammonium carbamate salts. However, the number, topology, and conformational features of the amino-functionalized arms present on the multivalent scaffold have a remarkable(More)
We describe an innovative approach to the generation of tetrameric water clusters in the solid state. The specific H-bond pattern induced by the tetraphosphonate cavitand template via its rigidly preorganized P=O acceptor groups leads to the exclusive formation of the unique cyclic homodromic water tetramer of C(4) symmetry.
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