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ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in a hypoxia-induced heterochromatin-like context. In certain hypoxic conditions, replication stress occurs in(More)
In this article we present the results of the investigation of an extraordinary piece appeared in the excavations of the Roman forum of Lucentum (Alicante, Spain) in 2005. It is a fragment of a bronze sculpture which is catalogued as a Unicum, that is, a work that presents some singular elements with no comparison with other examples of the Roman Art. This(More)
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