Monica M. Gressett

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Interest in combining radiotherapy and immune checkpoint therapy is growing rapidly. In this study, we explored a novel combination of this type to augment antitumor immune responses in preclinical murine models of melanoma, neuroblastoma, and head and neck squamous cell carcinoma. Cooperative effects were observed with local radiotherapy and intratumoral(More)
Method and materials C57BL/6 mice were engrafted with syngeneic GD2expressing B78 melanoma. Macroscopic tumors (~ 200 mm3) were treated with sham or single fraction 12 Gy RT. Mice then received 5 daily intra-tumor injections of human IgG, hu14.18 mAb, or hu14.18-IL2 IC. NK or T cell depletion was achieved by intraperitoneal injection of a depleting mAb(More)
BACKGROUND AND PURPOSE We recently reported a time-sensitive, cooperative, anti-tumor effect elicited by radiation (RT) and intra-tumoral-immunocytokine injection in vivo. We hypothesized that RT triggers transcriptional-mediated changes in tumor expression of immune susceptibility markers at delayed time points, which may explain these previously observed(More)
© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the(More)
We have identified a cooperative interaction between radiation and intratumoral injection of anti-GD2 immunocytokine (hu14.18-IL2) in murine tumor models. In a moderate size (~200 mm), single tumor, B78 melanoma model this combination results in complete tumor regression in 71% of animals and a memory T cell response. We hypothesized that intratumoral(More)
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