Monica Livia Gheorghiu

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The FTO (Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (n=207) and controls (n=100) from a Central European population. The(More)
To assess the role of the insulin receptor gene in polycystic ovary syndrome (PCOS) we performed a case-control study in a female population (n=226) from Central Europe by examining the genetic associations of single nucleotide polymorphisms (rs8107575, rs2245648, rs2245649, rs2963, rs2245655, and rs2962) and inferred haplotypes around exon 9 of this gene.(More)
Sepsis is a systemic, deleterious inflammatory host response triggered by an infective agent leading to severe sepsis, septic shock and multi-organ failure. The host response to infection involves a complex, organized and coherent interaction between immune, autonomic, neuroendocrine and behavioral systems. Recent data have confirmed that disturbances of(More)
9 Acta Endocrinologica (Buc), vol. X, no. 1, p. 9-20, 2014 *Correspondence to: Horea Ioan Ursu MD, “C. I. Parhon” Institute of Endocrinology, Thyroid Section, 34-36 Aviatorilor blvd., Bucharest, 011863, Romania, E-mail: horeaursu@hotmail.com Abstract Objective. To assess in a bicentric study the current iodine status of schoolchildren, ten years after(More)
INTRODUCTION Insulin gene VNTR was associated with polycystic ovary syndrome (PCOS) in some studies but not in others. This couldb be due to the heterogeneity of the definition of PCOS and/or the use of inappropriate gene mapping strategies. MATERIAL AND METHODS In this investigation, the association of VNTR with PCOS was explored in a population of women(More)
The authors have no conflicts of interest to disclose. Dear Sir, Increased generation of reactive oxygen species (ROS) is thought to play a role in the pathogenesis of Graves’ ophthalmopathy (GO) [1, 2] . Selenium (Se) is an antioxidant agent that has been recently shown to improve significantly the course of mild GO [2] . There is good evidence that(More)
INTRODUCTION In Romania no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral center which covers an important part of Romanian territory and population of patients with acromegaly. MATERIAL AND METHODS We reviewed the records of all 164 patients (49 males(More)
BACKGROUND Somatostatin analogs (SSA) are now considered standard therapy for acromegaly, as primary or adjunctive treatment after pituitary surgery. OBJECTIVE To evaluate the efficacy of SSA and the effect of dose escalation in non-operated patients with acromegaly as compared to patients treated after pituitary surgery in a Romanian tertiary care(More)
Purpose Treatment of acromegaly has undergone important progress in the last 20 years mainly due to the development of new medical options and advances in surgical techniques. Pituitary surgery is usually first-line therapy, and medical treatment is indicated for persistent disease, while radiation (RT) is often used as third-line therapy. The benefits of(More)
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