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AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio.… Expand
Germline mutations in LKB1, TSC2, or PTEN tumor suppressor genes result in hamartomatous syndromes with shared tumor biological features. The recent observations of LKB1-mediated activation of… Expand
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO The t(4;14)(p16.3;q32) translocation found in approximately 15% of patients with multiple myeloma leads to aberrant expression of 2 putative… Expand