Monica Fedele

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Alfredo Fusco, Monica Fedele
Nature Reviews Cancer
2007

The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription… (More)

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

Daniela Foti, Eusebio Chiefari, +9 authors Antonio Brunetti
Nature Medicine
2005

Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is… (More)

Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein.

Antonella Federico, Pierlorenzo Pallante, +11 authors Alfredo Fusco
Cancer research
2009

Chromobox protein homologue 7 (CBX7) is a chromobox family protein encoding a novel polycomb protein, the expression of which shows a progressive reduction, well related with the malignant grade of… (More)

CBX7 is a tumor suppressor in mice and humans.

Floriana Forzati, Antonella Federico, +10 authors Alfredo Fusco
The Journal of clinical investigation
2012

The CBX7 gene encodes a polycomb group protein that is known to be downregulated in many types of human cancers, although the role of this protein in carcinogenesis remains unclear. To shed light on… (More)

High level expression of the HMGI (Y) gene during embryonic development.

Gennaro Chiappetta, Virginia Avantaggiato, +9 authors Alfredo Fusco
Oncogene
1996

The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their… (More)

HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.

Monica Fedele, Rosa Visone, +10 authors Alfredo Fusco
Cancer cell
2006

HMGA2 gene amplification and overexpression in human prolactinomas and the development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role in pituitary… (More)

Role of the high mobility group A proteins in human lipomas.

Monica Fedele, Sabrina Battista, Guidalberto Manfioletti, Carlo M. Croce, Vincenzo Giancotti, Alfredo Fusco
Carcinogenesis
2001

The HMGA family is comprised of four proteins: HMGA1a, HMGA1b, HMGA1c and HMGA2. The first three proteins are products of the same gene, HMGA1, generated through an alternative splicing mechanism.… (More)

Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.

Gustavo Baldassarre, Sabrina Battista, +7 authors Alfredo Fusco
Molecular and cellular biology
2003

A drastic reduction in BRCA1 gene expression is a characteristic feature of aggressive sporadic breast carcinoma. However, the mechanisms underlying BRCA1 downregulation in breast cancer are not well… (More)

Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas

Monica Fedele, Sabrina Battista, +10 authors Alfredo Fusco
Oncogene
2002

Overexpression of the HMGA2 gene is a common feature of neoplastic cells both in experimental and human models. Intragenic and extragenic HMGA2 rearrangements responsible for HMGA2 gene… (More)

Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.

Rosa Marina Melillo, Giovanna Maria Pierantoni, +11 authors Alfredo Fusco
Molecular and cellular biology
2001

The high-mobility group I (HMGI) nonhistone chromosomal proteins HMGI(Y) and HMGI-C have been implicated in defining chromatin structure and in regulating the transcription of several genes. These… (More)

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