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Importance Cardiovascular disease (CVD), the leading cause of mortality and morbidity in the United States, may be potentially preventable with statin therapy. Objective To systematically review benefits and harms of statins for prevention of CVD to inform the US Preventive Services Task Force. Data Sources Ovid MEDLINE (from 1946), Cochrane Central(More)
BACKGROUND In 2009, the U.S. Preventive Services Task Force recommended biennial mammography screening for women aged 50 to 74 years and selective screening for those aged 40 to 49 years. PURPOSE To review studies of screening in average-risk women with mammography, magnetic resonance imaging, or ultrasonography that reported on false-positive results,(More)
BACKGROUND Previous research has supported screening for gonorrhea and chlamydia in asymptomatic, sexually active women (including pregnant women) who are younger than 25 years or at increased risk but not in other patient populations. PURPOSE To update the 2005 and 2007 systematic reviews for the U.S. Preventive Services Task Force on screening for(More)
BACKGROUND In 2009, the U.S. Preventive Services Task Force recommended biennial mammography screening for women aged 50 to 74 years and selective screening for those aged 40 to 49 years. PURPOSE To review studies of the effectiveness of breast cancer screening in average-risk women. DATA SOURCES MEDLINE and Cochrane databases to 4 June 2015. STUDY(More)
BACKGROUND Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a debilitating multisystem condition affecting more than 1 million adults in the United States. PURPOSE To determine benefits and harms of treatments for adults with ME/CFS and identify future research needs. DATA SOURCES MEDLINE, PsycINFO, and Cochrane databases (January 1988(More)
BACKGROUND The diagnosis of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is based on clinical criteria, yet there has been no consensus regarding which set of criteria best identifies patients with the condition. The Institute of Medicine has recently proposed a new case definition and diagnostic algorithm. PURPOSE To review methods to(More)
BACKGROUND Health information exchange (HIE), the electronic sharing of clinical information across the boundaries of health care organizations, has been promoted to improve the efficiency, cost-effectiveness, quality, and safety of health care delivery. OBJECTIVE To systematically review the available research on HIE outcomes and analyze future research(More)
BACKGROUND Vitamin D deficiency has been associated with adverse health outcomes. PURPOSE To systematically review benefits and harms of vitamin D screening in asymptomatic adults. DATA SOURCES Ovid MEDLINE (through the third week of August 2014), Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. STUDY(More)
IMPORTANCE Screening for syphilis infection is currently recommended for high-risk individuals, including those with previous syphilis infection, an infected sexual partner, HIV infection, or more than 4 sex partners in the preceding year. OBJECTIVE To update a 2004 systematic review of studies of syphilis screening effectiveness, test accuracy, and(More)
Background Dyslipidemia may occur in younger adults (defined as persons aged 21 to 39 years) and is an important risk factor for cardiovascular disease. Screening might identify younger adults with asymptomatic dyslipidemia who may benefit from lipid-lowering therapies. Purpose To update the 2008 U.S. Preventive Services Task Force review on dyslipidemia(More)