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Lowering external pH reduces peak current and enhances current decay in Kv and Shaker-IR channels. Using voltage-clamp fluorimetry we directly determined the fate of Shaker-IR channels at low pH by… Continue Reading
The effect of 4-aminopyridine (4-AP) on Kv channel activation has been extensively investigated, but its interaction with inactivation is less well understood. Voltage-clamp fluorimetry was used to… Continue Reading
Voltage-clamp fluorimetry (VCF) has been used to examine voltage sensor movement and the mechanism of coupling of activation to fast inactivation in the hERG potassium channel. Here, we used both… Continue Reading