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Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles.
Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications.
In this review, different polymers/molecules that can be used for nanoparticle coating to stabilize the suspensions of magnetic nanoparticles under in vitro and in vivo situations are discussed and some selected proteins/targeting ligands that could beused for derivatizing magnetic nanop particles are explored.
Microtubule-Associated Protein 1B-Light Chain 1 Enhances Activation of Rap1 by Exchange Protein Activated by Cyclic AMP but Not Intracellular Targeting
- G. Borland, Mona Gupta, M. Magiera, Catherine J Rundell, Suzanne Fuld, S. Yarwood
- Biology, ChemistryMolecular Pharmacology
- 21 October 2005
LC1 was able to enhance interaction of EPAC1 with cyclic AMP and heightened the ability ofEPAC to activate Rap1, and is therefore not involved in intracellular targeting of EPac1, but it is rather a molecular chaperone of EP AC activity toward Rap1.
Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts.
MAP1A Light Chain 2 Interacts with Exchange Protein Activated by Cyclic AMP 1 (EPAC1) to Enhance Rap1 GTPase Activity and Cell Adhesion*
LC2 is found to be a biological enhancer of EPAC1 activity toward Rap1 and associated downstream signaling mechanisms and cell adhesion to laminin was enhanced in LC2- andEPAC1-transfected cells stimulated with 8-CPT-2Me-cAMP.
In vitro cytotoxicity studies of hydrogel pullulan nanoparticles prepared by AOT/N-hexane micellar system.
- Mona Gupta, A. Gupta
- Biology, ChemistryJournal of pharmacy & pharmaceutical sciences : a…
- 13 February 2004
Results from cell adhesion/viability assay suggest that the pullulan nanoparticles are non-toxic to cells and do not cause any distinct harm to cells.
Estrogenic and antiestrogenic activities of 16α- and 2-hydroxy metabolites of 17β-estradiol in MCF-7 and T47D human breast cancer cells
Hydrogel pullulan nanoparticles encapsulating pBUDLacZ plasmid as an efficient gene delivery carrier.
Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A.
- M. Magiera, Mona Gupta, Catherine J Rundell, N. Satish, I. Ernens, S. Yarwood
- BiologyThe Biochemical journal
- 15 September 2004
Two-hybrid results suggest that the cAMP-binding domain of EPAC1 mediates interaction with LC2, which is associated with the perinuclear region surrounding the nucleus and filamentous structures throughout the cell.