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We describe a new cystatin in both mice and humans, which we termed leukocystatin. This protein has all the features of a Class II secreted inhibitory cystatin but contains lysine residues in the normally hydrophobic binding regions. As determined by cDNA library Southern blots, this cystatin is expressed selectively in hematopoietic cells, although fine(More)
There is growing evidence that neuronal apoptosis, or cell suicide, is likely to underlie a number of neurodegenerative disorders. The caspases are a growing family of cysteine proteases that execute the death program by proteolytic cleavage of a number of specific cellular substrates. Recent evidence suggests that they are also involved in processing of(More)
The DNA-binding domain of the mouse uterine estrogen receptor (ER) was characterized using site-specific polyclonal antibodies. The peptides used as antigens have sequences corresponding to amino acids 185-199 and 227-245, the two zinc finger regions of the DNA-binding domain of the human ER, and produced anti-sera designated A-1542 and A-1554,(More)
c-Abl is a tyrosine kinase involved in many cellular processes, including cell cycle control and proliferation. However, little is known about its substrates. Here, we show that c-Abl directly phosphorylates diacylglycerol kinase α (DGKα), an important regulator of many cellular events through its conversion of diacylglycerol to phosphatidic acid. We found(More)
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