Molly M. Malone

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BACKGROUND The beta2-adrenergic receptor (beta2AR) is expressed on numerous cell-types including airway smooth muscle cells and cardiomyocytes. Drugs (agonists or antagonists) acting at these receptors for treatment of asthma, chronic obstructive pulmonary disease, and heart failure show substantial interindividual variability in response. The ADRB2 gene is(More)
Twenty-nine (17 men, 12 women) collegiate track and field athletes were randomly divided into a creatine monohydrate (CM, n = 10) group, creatine monohydrate and glutamine (CG, n = 10) group, or placebo (P, n = 9) group. The CM group received 0.3 g creatine.kg body mass per day for 1 week, followed by 0.03 g creatine.kg body mass per day for 7 weeks. The CG(More)
Introduction: Lead augmented vector right (aVR) has been historically underestimated in the evaluation of acute coronary syndromes in the emergency department and other clinical settings. STelevation in aVR has shown to be a predictive marker of critical stenosis of the left main coronary and is associated with increased 30 day mortality. Case Report: We(More)
BACKGROUND Transitions in care create challenges for warfarin management, including dosing errors, medication nonadherence, and/or insufficient monitoring. Adverse drug events from warfarin following transitions have been found to have serious consequences. Before the intervention, at the time of hospital discharge, individual physicians identified warfarin(More)
An information package was developed for general practitioners (GPs) involved in the management of home parenteral nutrition (HPN) patients. The booklet covered five major sections: background information; HPN training; complications of HPN; arrangements for a particular patient; and hospital management of HPN. This study was designed to determine the(More)
A group of 34 patients who received home parenteral nutrition (HPN) were assessed by questionnaire to determine their knowledge of basic nutritional concepts, parenteral nutrition and the procedures used to monitor HPN. The results indicated that the HPN patients had an adequate knowledge of basic nutritional concepts and that this knowledge was not(More)
The limiting component within the receptor-G protein-effector complex in airway smooth muscle (ASM) for β(2)-adrenergic receptor (β(2)-AR)-mediated relaxation is unknown. In cardiomyocytes, adenylyl cyclase (AC) is considered the "bottleneck" for β-AR signaling, and gene therapy trials are underway to increase inotropy by increasing cardiac AC expression.(More)