Molly Holmes

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For over two decades, theorists have suggested that mania relates to heightened sensitivity of the behavioral activation system (BAS). In this article, we review a burgeoning empirical literature on this model, drawing on both cross-sectional and prospective studies. As evidence has emerged for this model, we argue that it is time to consider more specific(More)
OBJECTIVE Neuropsychological studies of bipolar disorder reveal deficits in a variety of domains, including affective processing, memory, and sustained attention. These findings are difficult to interpret due to the potential confounding effects of mood-stabilizing medications. The present study aims to compare the cognitive performance of medicated and(More)
OBJECTIVE Findings on spatial memory in depression have been inconsistent. A navigation task based on virtual reality may provide a more sensitive and consistent measure of the hippocampal-related spatial memory deficits associated with depression. METHOD Performance on a novel virtual reality navigation task and a traditional measure of spatial memory(More)
Bipolar disorder is associated with persistent declarative memory disturbances, but the neural basis of these deficits is not well understood. We used fMRI to investigate brain activity during performance on a face-name paired associate task, which allows for the dissociation of encoding and recall-related memory processes. Fifteen clinically remitted(More)
Anhedonia, a diminished or lack of ability to experience and anticipate pleasure represents a core psychiatric symptom in depression. Current clinician assessment of anhedonia is generally limited to one or two all-purpose questions and most well-known psychometric scales of anhedonia are relatively long, self-administered, typically not state sensitive,(More)
We investigated the nature of the memory mechanisms underlying cognitive bias modification by applying Jacoby's (1991) process-dissociation procedure to responses during the transfer task. In the two training conditions (negative and benign), students imagined themselves in 100 ambiguous scenarios, most with potentially negative resolutions; the ambiguity(More)
Two sources of information (parent-reported sleep diaries and actigraph records) were used to investigate how toddler sleep characteristics (bed time/sleep onset, wake time/sleep offset, total nighttime sleep, and total sleep time) are related to sleep problems and temperament. There were 64 toddler participants in the study. Consistent with studies of(More)
The ability of 60 EMR and 60 nonretarded children to acquire and retain a sorting and retrieval strategy designed to be facilitative of recall and clustering was examined. All subjects were given a baseline task and, based on their performance, were assigned to one of three groups: experimental, practice, and control. The experimental group received a(More)
  • M K Holmes
  • The Nursing clinics of North America
  • 1975
Working in a project where there are general objectives but no fixed program to reach them can be both a challenge and a frustration. But this work is never dull. The key points in the success of such a program are defined behavioral objectives for each student, an imaginative, flexible, and versatile nurse, and an administrative structure which is prepared(More)