Mojtaba Ghadiri

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Pharmaceutical powders are very prone to electrostatic charging by colliding and sliding contacts with walls and other particles. In pharmaceutical formulation processes, particle charging is often a nuisance and can cause problems in the manufacture of products, such as affecting powder flow, and reducing fill and dose uniformity. For a fundamental(More)
The influence of crystallographic structural anisotropy on the breakage behaviour of Aspirin under impact loading is highlighted. Under both quasi-static testing conditions, using nano-indentation, and dynamic impact tests, Aspirin demonstrates clear anisotropy in its slip and fracture behaviour. During nano-indentation on the (100) and (001) faces, cracks(More)
A novel approach has been developed for evaluating the milling behaviour of pharmaceutical powders based on their material and mechanical properties obtained by single particle impact testing. Milling behaviour of two widely used pharmaceutical excipients, namely microcrystalline cellulose and alpha-lactose monohydrate has been analysed in an oscillatory(More)
A simple method for using the JKR model to determine interfacial adhesion between two ideal rough surfaces is demonstrated for individual asperity-asperity and asperity-flat contacts both in air and in water. The model takes into account the effect of a modified contact area at separation due to viscoelastic effects. The equilibrium version of the model(More)
Some observations on the milling of alpha-lactose monohydrate with a Retsch single-ball mill are reported. The effects of mill loading and frequency of the mill motion were investigated. At a given frequency, a lower mill loading showed a higher milling efficiency. For a given mill loading, size reduction rate increased exponentially with frequency. The(More)
Catalytic steam reforming of glycerol for H(2) production has been evaluated experimentally in a continuous flow fixed-bed reactor. The experiments were carried out under atmospheric pressure within a temperature range of 400-700 degrees C. A commercial Ni-based catalyst and a dolomite sorbent were used for the steam reforming reactions and in situ CO(2)(More)
The dispersion of bulk powders is important for a number of applications including particle characterisation, and the delivery of therapeutic drugs via the lung using dry powder inhalers (DPIs). In recent years the distinct element method (DEM) coupled with continuum models for a fluid phase to simulate fluid–solids interactions has received much attention.(More)
Steam reforming of the crude glycerol by-product of a biodiesel production plant has been evaluated experimentally at atmospheric pressure, with and without in situ CO(2) sorption, in a continuous flow fixed-bed reactor between 400 degrees C and 700 degrees C. The process outputs were compared to those using pure glycerol. Thermodynamic equilibrium(More)
During particulate solid processing, particle-particle and particle-wall collisions can generate electrostatic charges. This may lead to a variety of problems ranging from fire and explosion hazards to segregation, caking, and blocking. A fundamental understanding of the particle charging in such situations is therefore essential. For this purpose we have(More)
Coating of particulate solids by a thin film layer is of interest in many industrial applications such as seed and tablet coating. In seed processing, seeds are commonly coated with a protective coating layer consisting of fertilisers and crop protection products. Rotary drum batch coaters are typically used for this purpose. The coater consists of a(More)