Moira Crosby McManus

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The mechanisms behind the development and spread of bacterial resistance to antimicrobial drugs are reviewed. The chief mechanisms by which antimicrobials act are interference with nucleic acid synthesis, binding to ribosomes, and inhibition of cell-wall synthesis and folate metabolism. Bacteria have evolved genetic and biochemical ways of resisting these(More)
Calmodulin-binding proteins have been identified in human platelets by using Western blotting techniques and 125I-calmodulin. Ten distinct proteins of 245, 225, 175, 150, 90, 82 (2), 60, and 41 (2) kilodaltons (kDa) bound 125I-calmodulin in a Ca2+-dependent manner; the binding was blocked by ethylene glycol bis(beta-aminoethyl ether)-N,N,N'N'-tetraacetic(More)
The historical development, pharmacology, pharmacodynamics, pharmacokinetics, clinical applications, pharmacologic basis for selection, adverse effects, and cost of neuromuscular blockers (NMBs) are discussed. The first NMB to be used was tubocurarine. During neurotransmission, acetylcholine is synthesized, stored in vesicles at the neuromuscular junction,(More)
The historical development, pharmacology, pharmacodynamics, pharmacokinetics, clinical applications, pharmacologic basis for selection, adverse effects, and cost of neuromuscular blockers (NMBs) are discussed. The first NMB to be used was tubocurarine. During neurotransmission, acetylcholine is synthesized, stored in vesicles at the neuromuscular junction,(More)
A TEST OF THE BEHAVIORAL MODEL OF HEALTH SERVICES USE ON NONEMERGENT EMERGENCY DEPARTMENT USE Moira Crosby McManus Old Dominion University, 2016 Co-Directors: Dr. Robert J. Cramer Dr. Bonnie Van Lunen Even though emergency departments (EDs) were created to treat trauma and emergent cases, there has been an increase in emergency department (ED) utilization(More)
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