Moin Saleem

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Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

Changli Wei, Shafic El Hindi, +25 authors Jochen Reiser
Nature Medicine
2011

Focal segmental glomerulosclerosis (FSGS) is a cause of proteinuric kidney disease, compromising both native and transplanted kidneys. Treatment is limited because of a complex pathogenesis,… (More)

A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression.

Moin Saleem, M J O'hare, +7 authors Peter H. Mundel
Journal of the American Society of Nephrology…
2002

Recent molecular insights have established the podocyte as a key component of the glomerular filtration barrier, and hence an important common pathway in proteinuric diseases. A conditionally… (More)

Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.

Bart Janssen, Daniela Hohenadel, +22 authors Fokko Johannes van der Woude
Diabetes
2005

The risk of diabetic nephropathy is partially genetically determined. Diabetic nephropathy is linked to a gene locus on chromosome 18q22.3-q23. We aimed to identify the causative gene on chromosome… (More)

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

Dawid G. Nowak, Jeanette Woolard, +6 authors David W Bates
Journal of cell science
2008

Vascular endothelial growth factor A (VEGFA; hereafter referred to as VEGF) is a key regulator of physiological and pathological angiogenesis. Two families of VEGF isoforms are generated by alternate… (More)

WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.

Elianna Mohamed Amin, Sebastian Oltean, +17 authors Michael R. Ladomery
Cancer cell
2011

Angiogenesis is regulated by the balance of proangiogenic VEGF(165) and antiangiogenic VEGF(165)b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor gene, suppress VEGF(165)b and cause… (More)

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.

Karin Schwarz, Matias Simons, +6 authors Peter H. Mundel
The Journal of clinical investigation
2001

NPHS2 was recently identified as a gene whose mutations cause autosomal recessive steroid-resistant nephrotic syndrome. Its product, podocin, is a new member of the stomatin family, which consists of… (More)

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.

Tobias B Huber, Matias Simons, +6 authors Thomas Benzing
Human molecular genetics
2003

Hereditary nephrotic syndrome is a heterogeneous disease, characterized by heavy proteinuria and renal failure. Mutations of NPHS1 or NPHS2, the genes encoding for nephrin and podocin, lead to early… (More)

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption.

Shazia Ashraf, Heon Yung Gee, +42 authors Friedhelm Hildebrandt
The Journal of clinical investigation
2013

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has furthered the understanding of the pathogenesis of this disease. Here, using a combination of homozygosity… (More)

Insulin signaling to the glomerular podocyte is critical for normal kidney function.

Gavin I. Welsh, Lorna J. Hale, +17 authors Richard J. M. Coward
Cell metabolism
2010

Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is considered a hyperglycemic "microvascular"… (More)

The human glomerular podocyte is a novel target for insulin action.

Richard J. M. Coward, Gavin I. Welsh, +9 authors Moin Saleem
Diabetes
2005

Microalbuminuria is significant both as the earliest stage of diabetic nephropathy and as an independent cardiovascular risk factor in nondiabetic subjects, in whom it is associated with insulin… (More)

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