Learn More
Amphiphilic biodegradable core-shell nanoparticles were prepared by emulsification-solvent evaporation technique from diblock copolymers which were synthesized by chemical coupling of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) P(3HB-co-3HV) or poly(3-hydroxybutyrate-co-4-hydroxybutyrate) P(3HB-co-4HB) to monomethoxy poly(ethylene glycol) (mPEG) through(More)
Despite several advancements in chemotherapy, cancer is still the second most frequent cause of mortality worldwide. Drug delivery to solid tumors is one of the most challenging aspects in cancer therapy. In pharmaceutical industries biodegradable polymeric nanoparticles as drug carriers have attracted great research interest because of their(More)
Cisplatin is a chemotherapeutic agent used against a variety of tumors. We determined the efficacy and bioavailability of cisplatin in the form of cisplatin-loaded self-assembled amphiphilic copolymer nanoparticles (NPs). Non-crystallizing bacterial copolyester was employed as hydrophobic segment to increase drug loading efficiency. Novel amorphous(More)
The aim of this study is to prepare amphiphilic biodegradable core-shell nanoparticles using poly(3hydroxybutyrate-co-4hydroxybutyrate) copolymer as hydrophobic core and monomethoxy poly(ethylene glycol) as outer hydrophilic shell. The nanoparticles were prepared by emulsification-solvent evaporation technique using sodium deoxycholate as emulsifier.(More)
When dealing with nano targeted drug delivery process the significant area of virtual reality application can be visualizing real time process and simulating it at nano-scale, since the effectiveness of a drug primarily depends on the affected cell and targeted doze. This paper proposes virtual reality (VR) as a tool to analyze and simulate nanoparticles(More)
  • Mohsin Shah
  • JPMA. The Journal of the Pakistan Medical…
  • 2008
Madam, Bronchial Thermoplasty is a novel approach aimed at alleviating the painful symptoms associated with asthma. Bronchial Thermoplasty is done using the Alair® system which consists of a single catheter and a controller that delivers radio frequency energy to apply controlled heat on the smooth muscles of the airway to relieve asthma symptoms.1 As the(More)
Despite the recent research interest in the field of nanoparticles delivery system, their structure modification and transport behavior of various hydrophobic drugs is poorly developed. In this article the synthesis of novel amphiphilic diblock copolymer poly([R]-3-hydroxyvalerate)-block-monomethoxy poly(ethylene glycol) (PHV-block-mPEG) was undertaken by(More)
  • 1