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Metabolic remodeling is now widely regarded as a hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours. Here we compare messenger RNA profiles of 1,454 metabolic enzymes across 1,981 tumours spanning 19 cancer types to identify enzymes that are consistently differentially expressed. Our(More)
BACKGROUND Morquio A syndrome (or mucopolysaccharidosis IVa) is an ultra-rare multi-organ disease, resulting in significantly impaired functional capacity, mobility and quality of life (QoL). METHODS This patient-reported outcomes survey evaluated the global burden of Morquio A among adults (≥18 years, N = 27) and children (7-17 years, N = 36), including(More)
— In recent times, many protocols have been proposed to provide security for various information and communication systems. Such protocols must be tested for their functional correctness before they are used in practice. Application of formal methods for verification of security protocols would enhance their reliability thereby, increasing the usability of(More)
The majority of inherited mitochondrial disorders are due to mutations not in the mitochondrial genome (mtDNA) but rather in the nuclear genes encoding proteins targeted to this organelle. Elucidation of the molecular basis for these disorders is limited because only half of the estimated 1,500 mitochondrial proteins have been identified. To systematically(More)
  • Sonia Sharma, Ariel Quintana, Gregory M Findlay, Marcel Mettlen, Beate Baust, Mohit Jain +3 others
  • 2013
The STIM1-ORAI1 pathway of store-operated Ca(2+) entry is an essential component of cellular Ca(2+) signalling. STIM1 senses depletion of intracellular Ca(2+) stores in response to physiological stimuli, and relocalizes within the endoplasmic reticulum to plasma-membrane-apposed junctions, where it recruits and gates open plasma membrane ORAI1 Ca(2+)(More)
Most organizations in the developing world still rely on paper for record keeping, giving rise to many problems in aggregation, storage, transmission and analysis of data. Errors and time delays associated with paper data are particularly problematic in the domain of healthcare. We present a case study of CommCare, a low-cost mobile phone data collection(More)
Forty percent of the world's population, including a significant portion of the rural and urban poor sections of the population in India, does not have access to reliable electricity supply. Concurrently, there is rapid penetration of battery-operated portable computing devices such as laptops, both in the developing and developed world. This generates a(More)
Rapid depletion of fossil fuels and water resources has become an international problem. Urban residential households are among the primary consumers of resources and are deeply affected by resource shortages. Despite the global nature of these problems, most of the solutions being developed to address these issues are based on studies done in the developed(More)
Though rapid depletion of natural resources has become a global problem, most of the solutions developed to address it are based on studies done in the developed world. Moreover, the commercial sector is among the primary consumers of resources, yet research work has been mostly limited to residential users. We present a study exploring employees'(More)