Mohini Aiyengar Tupurani

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Apoptosis has been involved in a number of pathological conditions including coronary artery disease (CAD). Caspases (CASP) are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways. The aim of the present study is to examine the role of Caspase 8 and 3 polymorphisms in the pathogenesis of CAD. CAD patients (n=300) and(More)
Breast cancer is the most common form of cancer worldwide. It is a potential life-threatening malignancy in women. The incidence of breast cancer is rising in developing countries such as, India. Most breast malignancies arise from epithelial elements and are categorized as carcinomas. Breast carcinomas are a diverse group of lesions that differ in(More)
BACKGROUND Extracellular matrix degradation by matrix metalloproteinases (MMPs) is an important mechanism involved in tumor invasion and metastasis. Genetic variations of MMPs have shown association with multiple cancers. The present study is focused to elucidate the association of MMP-1, 3 and 9 genetic variants with respect to epidemiological and(More)
Type 2 Diabetes mellitus (T2DM) is a chronic disorder of impaired insulin secretion and insulin resistance leading to hyperglycemia. In addition to hyperglycemia, dyslipidemia is a characteristic feature of T2DM. Progressive deterioration of beta-cell mass and function are the core pathogenic mechanisms underlying diabetes. Persistent hyperglycemia and(More)
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