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Client protein recruitment to the Hsp90 system depends on cochaperones that bind the client and Hsp90 simultaneously and facilitate their interaction. Hsp90 involvement in the assembly of snoRNPs, RNA polymerases, PI3-kinase-like kinases, and chromatin remodeling complexes depends on the TTT (Tel2-Tti1-Tti2), and R2TP complexes-consisting of the AAA-ATPases(More)
  • Mohinder Pal, T. N. Khoshoo
  • 1973
Of the four interspecific hybrids, three (A. graecizans var. graecizans X A. tricolor cv. ‘Purple leaf’, A. lividus var. lividus X A. tricolor var. viridis and A. gracilis X A. tricolor cv. ‘Purple leaf’) were studied cytologically. In all the three, differentiation between the parents is chiefly a result of interchanges and paracentric inversions. The(More)
Specific co-chaperone adaptors facilitate the recruitment of client proteins to the Hsp90 system. Tah1 binds the C-terminal conserved MEEVD motif of Hsp90, thus linking an eclectic set of client proteins to the R2TP complex for their assembly and regulation by Hsp90. Rather than the normal complement of seven α-helices seen in other tetratricopeptide repeat(More)
A previously uncharacterized species of the genus Arthrobacter, strain IHBB 11108 (MCC 2780), is a Gram-positive, strictly aerobic, nonmotile, cold-adapted, and protease-producing alkaliphilic actinobacterium, isolated from shallow undersurface water from Chandra Tal Lake, Lahaul-Spiti, India. The complete genome of the strain is 3.6 Mb in size with an(More)
The complete genome sequence of 5.77 Mb is reported for Paenibacillus sp. strain IHBB 10380, isolated from the cold desert area of the northwestern Himalayas and exhibiting amylase and cellulase activities. The gene-coding clusters predicted the presence of genes for hydrolytic enzymes in the genome.
A. spinosus is a spinous and noxious weed with 17 II, while A. dubius is the only polyploid (4x) species of the genus with 32 II and is commonly used as a pot herb. The natural hybridization is far more successful (upto 80%) with the diploid as the female parent. The most common configurations in the triploid hybrid are 17II + 15I and 1 I V + 15II + 15I.(More)
The cold-active esterases are gaining importance due to their catalytic activities finding applications in chemical industry, food processes and detergent industry as additives, and organic synthesis of unstable compounds as catalysts. In the present study, the complete genome sequence of 4,843,645 bp with an average 34.08% G + C content and 4260(More)
The R2TP complex, comprising the Rvb1p-Rvb2p AAA-ATPases, Tah1p, and Pih1p in yeast, is a specialized Hsp90 co-chaperone required for the assembly and maturation of multi-subunit complexes. These include the small nucleolar ribonucleoproteins, RNA polymerase II, and complexes containing phosphatidylinositol-3-kinase-like kinases. The structure and(More)
While the two parents of the hybrid have 17 and 32 chromosomes respectively, the hybrid commensurate with its meiosis, has a variety of chromosome numbers in pollen grains. On the basis of their size, the grains may be grouped in two categories: macropollen (21–26μ; 77%) and micropollen (8–14μ; 23%). These contain 19–27 and 1–4 chromosomes respectively.(More)
Tetratricopeptide (TPR) domains are known protein interaction domains. We show that the TPR domain of FKBP8 selectively binds Hsp90, and interactions upstream of the conserved MEEVD motif are critical for tight binding. In contrast FKBP8 failed to bind intact Hsp70. The PPIase domain was not essential for the interaction with Hsp90 and binding was(More)
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