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Nicotine can increase stimulus detection, response rate and speed in the five-choice serial reaction time task, a rodent test of attention. In the present experiments, four other nicotinic agonists with different pharmacological profiles were compared in the same procedure. The response profile of epibatidine resembled that previously obtained with nicotine(More)
— In low-power sensing systems, communication constraints play a critical role; e.g., biomedical devices often acquire physiological signals from distributed sources and/or wireless implants. Compressive sensing enables sub-Nyquist sampling for low-energy data reduction on such nodes. The reconstruction cost, however, is severe, typically pushing signal(More)
RATIONALE Nicotine can enhance attentional performance in humans, a property that may be of therapeutic utility. OBJECTIVES To identify brain sites mediating nicotine-induced attentional enhancement. METHODS Nicotine (0, 1, 2, 4 and 8 microg) was injected bilaterally into the dorsal hippocampus and the prelimbic area of the prefrontal cortex, brain(More)
A key challenge in closed-loop chronic biomedical systems is the ability to detect complex physiological states from patient signals within a constrained power budget. Data-driven machine-learning techniques are major enablers for the modeling and interpretation of such states. Their computational energy, however, scales with the complexity of the required(More)
Supervised machine-learning algorithms are used to solve classification problems across the entire spectrum of computing platforms, from data centers to wearable devices, and place significant demand on their computational capabilities. In this paper, we propose <i>scalable-effort classifiers</i>, a new approach to optimizing the energy efficiency of(More)
InVivoStat is a free-to-use statistical software package for analysis of data generated from animal experiments. The package is designed specifically for researchers in the behavioural sciences, where exploiting the experimental design is crucial for reliable statistical analyses. This paper compares the analysis of three experiments conducted using(More)
Nicotinic agonists have been shown to enhance performance in cognitive tasks based on attention and memory. The aim of this study was to use a test of olfactory working memory; the odour span task (OST) in rodents, to investigate the effects of subtype-specific nicotinic agonists on working memory in normal rats. Rats were trained in a non-matching to(More)
Ketamine, an NMDA-receptor antagonist, produces cognitive deficits in humans in a battery of tasks involving attention and memory. Nicotine can enhance various indices of cognitive performance, including working memory span capacity measured using the odor span task (OST). This study examined the effects of a sub-chronic ketamine treatment to model(More)
The endocannabinoid system has been implicated in the motivational effects of nicotine and nicotine-associated stimuli but the neural circuitry underlying tobacco addiction is not fully characterised. The present study aimed to establish a second-order schedule of nicotine reinforcement to compare the role of the endocannabinoid system in nicotine- and(More)
Nicotine enhances attentional and working memory aspects of executive function in the prefrontal cortex (PFC) where dopamine plays a major role. Here, we have determined the nicotinic acetylcholine receptor (nAChR) subtypes that can modulate dopamine release in rat PFC using subtype-selective drugs. Nicotine and 5-Iodo-A-85380 (beta2* selective) elicited(More)