Mohammed S. A. Suhail

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Botulinum neurotoxin B (BoNT-B) mediates proteolytic cleavage of VAMP I/II (synaptobrevins I/II), which prevents vesicle-membrane fusion and blocks neurotransmitter release. In the present study, we investigated the effects of BoNT-B on neurotransmitter release in vivo from spinal primary afferent sensory fibers and the effects of this blockade on(More)
PURPOSE To provide direct evidence that mechanical obstruction of microvessels inhibits infarct resorption (healing) and enhances left ventricular (LV) remodeling using MRI. MATERIALS AND METHODS Animals (n = 20 pigs) served as controls (group I) or were subjected to either 90 min left anterior descending (LAD) coronary artery occlusion/reperfusion (group(More)
Purpose To determine if high lung shunt fraction (LSF) is an independent prognostic indicator of poor survival in patients who undergo yttrium 90 radioembolization for unresectable liver-dominant metastatic colorectal cancer. Materials and Methods Retrospective data were analyzed from 606 patients (62% men; mean age, 62 years) who underwent(More)
AIM To compare the acute changes in circumferential and longitudinal strain after exposing a coronary artery to various interventions in swine. METHODS Percutaneous balloon angioplasty catheter was guided to location aid device (LAD) under X-ray fluoroscopy to create different patterns of ischemic insults. Pigs (n = 32) were equally divided into 4 groups:(More)
An esophageal diverticulum is seen in a variety of gastroesophageal conditions, with most having an underlying motility disorder. The diverticulum is diagnosed by combining the patient's history, physical examination, computed tomographic chest scan, and barium radiography. We present an unusual case of a 43-year-old patient with a history of leiomyoma(More)
Chronic pain has profound effects on activity. Previous reports indicate chronic inflammatory conditions result in reduced activity which normalizes upon pain treatment. However, there is little systematic investigation of this process. Rheumatoid arthritis is an autoimmune disorder that causes significant joint pain. The K/BxN serum transfer mouse has been(More)
Background Microvascular obstruction is a major problem after reperfusion therapy of AMI. A recent study reported that longitudinal and circumferential strain after reperfusion therapy is an excellent predictor of left ventricular (LV) dysfunction in patients with anterior wall AMI [1,2]. In the current MRI investigation, we adapted a method routinely used(More)
Traditional algorithms for training the Support Vector Machines (SVMs) have a worst case time complexity of O(n3) and a space complexity of O(n2). This makes it difficult to scale the training algorithm for large scale datasets. In this paper, three algorithms have been proposed for reducing the training dataset. The algorithms mine the potential support(More)
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