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OBJECTIVE To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. METHODS A total of 331… (More)
OBJECTIVE To evaluate the efficacy and tolerability of prolonged administration of quinapril, a long-acting angiotensin-converting enzyme inhibitor, in the management of the peripheral vascular manifestations of limited cutaneous systemic sclerosis (lcSSc) and in the prevention of the progression of visceral organ involvement in the disease. METHODS This… (More)
Sulphasalazine (SASP) and methotrexate (MTX) are well-established treatments for RA but the use of these drugs in combination has been avoided as both have antifolate activity. In this paper we report our experience with 32 patients treated with the combination MTX/SASP and compare the toxicity and tolerability of the combination with 63 patients treated… (More)
BACKGROUND The present study was planned to observe the hypoglycemic effect of the 'Ficus relegiosa', a traditional medicinal plant. This study was performed to study the possible role of indigenous medicinal plants in the treatment of Diabetes mellitus (type-2) METHODS Normal rabbits were divided into 5 groups (1-5) of six animals each. Group I served as… (More)
We describe a case of severe colitis in a 40-year-old woman early in the course of intramuscular gold therapy for rheumatoid arthritis. Despite prompt withdrawal of gold, our patient required emergency laparotomy and bowel decompression. Incidental cholestatic hepatotoxicity, a further rare adverse reaction to gold, was also noted in our patient.
Atlanto-occipital subluxation is a rare but recognized form of subluxation that occurs in rheumatoid arthritis (RA) at the cranio-cervical junction. Magnetic resonance imaging (MRI) clearly demonstrates the bony and soft tissue changes of RA in the cervical spine. We report a single case of atlanto-occipital subluxation in RA demonstrated by MRI.