Mohammed J. Zaman

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By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous(More)
OBJECTIVE To determine whether cardiothoracic ratio (CTR), within the range conventionally considered normal, predicted prognosis in patients undergoing coronary angiography. DESIGN Cohort study with a median of 7-years follow-up. SETTING Consecutive patients undergoing coronary angiography at Barts and The London National Health Service (NHS) Trust. (More)
BACKGROUND To investigate the prevalence, screening and knowledge of cardiovascular risk factors (CVRFs) by socio-economic position (SEP) in rural India. METHODS An age- and sex-stratified random sample of 4535 adults was recruited from rural Andhra Pradesh and a questionnaire was administered to assess prevalence, screening and knowledge of CVRFs and(More)
BACKGROUND AND PURPOSE Anti-inflammatory cytokine and its genetic variations may play an important role in the process of atherosclerosis. We assessed whether serum interleukin-10 (IL-10) and its genetic variations are associated with ischemic stroke in a Chinese general population. METHODS An epidemiological survey on cardiovascular diseases and their(More)
AIMS Older people increasingly constitute a large proportion of the acute coronary syndrome (ACS) population. We examined the relationship of age with receipt of more intensive management and secondary prevention medicine. Then, the comparative association of intensive management (reperfusion/angiography) over a conservative strategy on time to death was(More)
INTRODUCTION Coronary heart disease (CHD) is the leading cause of mortality worldwide. With increasingly urbanized lifestyles in developing countries and the aging populations, the major risk factors for CHD such as obesity, diabetes mellitus, and hypercholesterolemia are likely to increase in the future. In the current report, we reviewed the evidence on(More)
The '10/90 gap' was first highlighted by the Global Forum for Health Research. It refers to the finding that 90% of worldwide medical research expenditure is targeted at problems affecting only 10% of the world's population. Applying research results from the rich world to the problems of the poor may be a tempting, potentially easy and convenient solution(More)
A patient presented to a district general hospital with a type B dissection of the aorta. He was deemed too unwell for surgical intervention. An endovascular stent repair was successfully carried out. The case shows that such a procedure can be safely performed by a multidisciplinary team within a district general hospital.
BACKGROUND It is not known whether there are disparities in morbidity outcomes between south Asians and whites with established coronary disease. METHODS Six-year prospective cohort study to determine whether improvement of angina symptoms differs between 196 south Asians and 1508 whites following revascularization or medical management. RESULTS 43.9%(More)
SIR—Cardiac troponins are highly sensitive and specific biomarkers for myocardial injury [1]. Furthermore, in the context of an acute coronary syndrome (ACS), baseline elevations of troponin have prognostic significance, with a higher risk of death or recurrent infarction early after presentation in patients with a raised troponin [2]. Although troponin is(More)