Mohammed Al-Jumaily

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Whole cell patch-clamp recordings of calcium-activated chloride current [ICl(Ca)] were made from adult sensory neurons of naive and axotomized mouse L4-L6 lumbar dorsal root ganglia after 1 day of culture in vitro. A basal ICl(Ca) was specifically expressed in a subset of naive medium-diameter neurons (30-40 microm). Prior nerve injury, induced by sciatic(More)
OBJECT Endoscopic third ventriculostomy (ETV) is the treatment of choice for hydrocephalus, but the outcome is dependent on the cause of this disorder, and the procedure remains principally the preserve of pediatric neurosurgeons. The role of ETV in adult patients with hydrocephalus was therefore investigated. METHODS One hundred ninety adult patients(More)
In order to shed light on transcriptional networks involved in adult peripheral nerve repair program, we propose for the first time an organization of the transcriptional dynamics of the mouse dorsal root ganglia (DRG) following a sciatic nerve lesion. This was done by a non-hierarchical bioinformatical clustering of four Serial Analysis of Gene Expression(More)
OBJECTIVE We aimed to study a group of patients presenting with symptomatic longstanding overt ventriculomegaly in adults (LOVA) requiring treatment (endoscopic third ventriculostomy), and to study their long term neuropsychological status and functionality. METHODS Twenty patients were treated with endoscopic third ventriculostomy on presentation and(More)
Heart failure comes in the top causes of death worldwide. The number of deaths from heart failure exceeds the number of deaths resulting from any other causes. Recent studies have focused on the use of machine learning techniques to develop predictive models that are able to predict the incidence of heart failure. The majority of these studies have used a(More)
Hyperexcitability of axotomized dorsal root ganglion neurons is thought to play a role in neuropathic pain. Numerous changes in ionic channels expression or current amplitude are reported after an axotomy, but to date no direct correlation between excitability of axotomized sensory neurons and ionic channels alteration has been provided. Following sciatic(More)
A calcium-activated chloride current (I Cl(Ca)) has been observed in medium-sized sensory neurons of the dorsal root ganglion (DRG). Axotomy of the sciatic nerve induces a similar current in the majority of medium and large diameter neurons. Our aim is to identify the molecule(s) underlying this current. Using conventional and quantitative RT-PCR, we(More)
Back pain is one of the major musculoskeletal pain problems that can affect many people and is considered as one of the main causes of disability all over the world. Lower back pain, which is the most common type of back pain, is estimated to affect at least 60% to 80% of the adult population in the United Kingdom at some time in their lives. Some of those(More)
The problem of excess cerebrospinal fluid in the brain (hydrocephalus) is generally managed using a passive pressure or flow regulated mechanical shunt. Despite the success of such devices, they have been plagued with a number of problems. It is desirable to have a shunt valve that responds dynamically to the changing needs of the patient, opening and(More)
Intelligent clinical decision support systems have been increasingly used in health care organisations. These systems are intended to help physicians in their diagnosis procedures; making decisions more accurate and effective, minimising medical errors, improving patient safety and reducing costs. However, the effectiveness and accuracy of these systems(More)