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Our objective was the preclinical assessment of the pharmacokinetics, monotherapy and combined antitumor activity of the epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor erlotinib in athymic nude mice bearing non-small cell lung cancer (NSCLC) xenograft models. Immunohistochemistry determined the HER1/EGFR status of the NSCLC tumor(More)
Erlotinib (Tarceva®, OSI-774) is a potent, orally available, small-molecule inhibitor of HER1/EGFR tyrosine-kinase activity. In this study, the antitumor activity of erlotinib was evaluated in two human colorectal tumor xenograft models (LoVo and HCT116) in athymic mice. When erlotinib was administered as monotherapy, significant tumor growth inhibition(More)
A comprehensive study has been made of the fluxes of selected pollutants emitted from a major rural highway in NW England. Lead, cadmium, copper, the organic compounds of lead and 8 PAH species have been studied and their fluxes measured in bulk deposition samples in transects away from the road in the road runoff waters and its associated sediments and in(More)
—In this paper a novel configuration of broadband multi slot antenna for C/X bands is presented and analyzed. By cutting two diamond slots in the middle of the rectangular patch and three triangular slots in the right side of the patch, resonances can be created. Microstrip feed line is used in the down side region of the patch. Antenna characteristics were(More)
We intend and design a new type of mobile handset antenna structure to reduce the specific absorption rate (SAR) in human head. The designed of low SAR handset antenna will be operating at 2.4 GHz frequency for wireless local area network (WLAN) by considering some parameters that determine the performance of the antenna. The authors carried out simulation(More)
The aim of this paper, a comparative study of several antennas commonly used in portable telephones is investigated. These include a monopole, a helical, a patch and a PIFA antenna. Each one of these structures is modelled and numerically tested using CST Microwave Studio. The testing procedure involves antenna simulation in the proximity of the human head(More)
Magneto-inductive (MI) waveguides are linear arrangements of magnetically coupled L–C resonators that propagate electrical energy at radio frequency without direct connection. To achieve the strong magnetic coupling needed for low-loss propagation, adjacent elements must be in such close proximity that electric coupling arises. In contrast to electric(More)
The reducing specific absorption rate (SAR) with metamaterials attachment is investigated in this paper. The finite-difference time-domain method with lossy-Drude model is adopted in this analysis. The technique of SAR reduction is discussed and the effects of attaching location, distance, and size of metamaterials, perfect electric conductor (PEC), and(More)
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