Mohammad R. Al-Magableh

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This study aimed to elucidate the molecular mechanism of H2S-induced vasorelaxation. Vasorelaxation responses to the H2S donor NaHS and the H2S precursor l-cysteine were examined by measuring isometric tone of mouse aortic rings in a small vessel myograph. H2S concentrations in Krebs' solution were determined with a polarographic sensor. H2S expression was(More)
The aim of this study was to examine the ability of H2S, released from NaHS to protect vascular endothelial function under conditions of acute oxidative stress by scavenging superoxide anions (O2 −) and suppressing vascular superoxide anion production. O2 − was generated in Krebs' solution by reacting hypoxanthine with xanthine oxidase (Hx-XO) or with the(More)
Hydrogen sulfide (H2S) is increasingly recognized as a gasotransmitter with protective effects in the cardiovascular system. The aim of the study was to examine the effects of chronic NaHS treatment on blood pressure, vascular function and oxidative stress in an in vivo model of hypertension and oxidative stress. Male C57Bl6/J mice were rendered(More)
Hydrogen sulfide is emerging as an important mediator of vascular function that has antioxidant and cytoprotective effects. The aim of this study was to investigate the role of endogenous H2S and the effect of chronic exogenous H2S treatment on vascular function during the progression of atherosclerotic disease. ApoE(-/-) mice were fed a high-fat diet for(More)
Hydrogen sulfide (H(2)S) is now recognized as an important signaling molecule and has been shown to have vasodilator and cardio-protectant effects. More recently it has been suggested that H(2)S may also act within the brain to reduce blood pressure (BP). In the present study we have demonstrated the presence of the H(2)S-producing enzyme,(More)
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