Mohammad Pooya

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We evaluated the role of the osmolarity in the pro-inflammatory responses of epithelial cells. Twenty-five female Wistar rats and colorectal (HT-29) and bladder (T24) cell lines were used. Rats and cells were exposed for 48 hours to hyperosmotic solutions. Interleukin-8 (IL-8) production was measured by Enzyme Linked ImmunoSorbent Assay, mRNA transcription(More)
There are several reports suggesting that hyperosmolarity induces inflammation. We recently showed that Dextran Sodium Sulfate causes inflammatory bowel disease due to hyperosmolarity. The aim of this study was to confirm the link between hyperosmolarity and inflammation by assessing osmolarity values in vivo during inflammation, compare the inflammatory(More)
Although in the last two decades the World Health Organization (WHO) has introduced tuberculosis as "a threat to global", the vaccination with the Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is the only way for the prevention of this fatal infectious disease. Despite of the efficacy of BCG vaccine especially against infants' meningitis, it has still(More)
The bladder is the most common site of cancer in the urinary tract and bladder cancer is the fourth and eighth most common cancer in men and women respectively. Bladder cancer can be divided into superficial and muscle invasive cancer. Superficial bladder cancer involves the bladder wall no deeper than the subepithelial tissue. The standard treatment of(More)
1Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran; 2Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran; 3Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran, Iran; 4Infectious Diseases ward, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences,(More)
There are several reports suggesting hyperosmotic contents in the feces of patients suffering from inflammatory bowel disease (IBD). Previous works have documented that hyperosmolarity can cause inflammation attributable to methylation of the catalytic subunit of protein phosphatase 2A (PP2A) and subsequent NF-kappaB activation resulting in cytokine(More)
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