Mohammad Mohsin Khan

Learn More
Abnormal membrane phospholipid essential polyunsaturated fatty acid (EPUFA) metabolism (i.e., reduced incorporation into phospholipids and increased breakdown) has been suggested to contribute to the etiopathophysiology of schizophrenia. However, most of the published studies have reported changes in the levels of membrane EPUFA in chronic medicated(More)
Typical and atypical antipsychotics significantly differ in their neurotransmitter receptor affinity profiles, and their efficacy and side effects in schizophrenic patients. Typical antipsychotics have been found to increase the oxidative (i.e. free radical-mediated) cellular injury in rats. Since schizophrenia also involves oxidative injury, the(More)
Recently, we reported that compared to haloperidol, chronic exposure to either the risperidone (RISP) or olanzapine (OLZ) resulted in superior effects on spatial learning performance as well as the cholinergic neurons, although the mechanism for these effects was not addressed. The objective of this study was to investigate one plausible mechanism whereby(More)
Nerve growth factor (NGF) has been found to play a crucial role in the neuroplasticity of predominantly cholinergic neurons in brain development, and neuronal survival following brain injury, which reflect in cognitive performance. Wide ranges of neurodevelopmental abnormalities have been reported in schizophrenic patients, who also show poor cognitive(More)
Previously we reported that chronic exposure to haloperidol (HAL), but not the atypical antipsychotics risperidone (RISP) or clozapine (CLOZ), resulted in reductions in brain choline acetyltransferase (ChAT) immunoreactivity and impaired water maze task performance in rats. In the present study, we compared the effects of these antipsychotic drugs on the(More)
Recently, we have reported studies in rats showing that the atypical antipsychotic olanzapine (OLZ), in contrast to haloperidol (HAL), was not associated with reduction of markers of central cholinergic neurons as well as decrements in cognitive performance after chronic exposure. We compared the effect of 45 day chronic exposure of HAL (2 mg/kg per day) to(More)
Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients. We studied the plasma apoD levels in never-medicated schizophrenic(More)
Case report A 42 years old male presented to a general physician with complaints of progressive symptoms of lower back ache, fatigue, anaemia, weight loss and mild fever. Initial diagnosis on clinical grounds was abdominal tuberculosis but on ultrasonography (USG), a hypoechoic mass encircling the aorta, inferior vena cava (IVC) and ureters at the aortic(More)
Background: This study was on all Fire Arm injuries deaths which were received for autopsies in Forensic Medicine Department, Allam Iqbal Medical College Lahore during the year 2014.The objective was to be carried out a retrospective analysis of 114 autopsies due to Fire Arm injuries Deaths The relationship of age and gender was focused. Methods: Total(More)
Upper GI hemorrhage is a serious medical emergency. It is a common cause for hospital admission worldwide. The source of hemorrhage is usually gastroesophageal varices, peptic ulcer, acute gastric erosions, Mallory-Weis tear and erosive esophagitis. Less common causes are upper GI malignancies, coagulation disorders, AV malformations and connective tissue(More)