Mohammad Mirzadeh

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We employ optimal control theory to design an event-based, minimum energy, desynchronizing control stimulus for a network of pathologically synchronized, heterogeneously coupled neurons. This works by optimally driving the neurons to their phaseless sets, switching the control off, and letting the phases of the neurons randomize under intrinsic background(More)
In this paper we present a nite dierence scheme for the discretization of the nonlinear Poisson-Boltzmann(PB) equation over irregular domains that is second-order accurate. The interface is represented by a zero level set of a signed distance function using Octree data structure, allowing a natural and systematic approach to generate non-graded adaptive(More)
— With inspiration from Arthur Winfree's idea of randomizing the phase of an oscillator by driving its state to a set in which the phase is not defined, i.e., the phaseless set, we employ a Hamilton-Jacobi-Bellman approach to design a minimum energy control law that effectively randomizes the next spiking time for a two-dimensional conductance-based model(More)
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