Mohammad Mahdi Eftekharian

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Retinoic acid receptor-related orphan receptor alpha (RORA) is proposed to promote Th17 cells differentiation that play a crucial role in many inflammatory diseases, including multiple sclerosis (MS). The gene is also involved in regulation of inflammatory responses and neuronal cell development. The aim of the present study is to determine if any relation(More)
Multiple sclerosis (MS) is a chronic disorder resulting from destruction of the myelin or insulating covers of neurons in the central nervous system (CNS). Several lines of evidence suggest a role for immune response in the occurrence and progression of this disorder. Several disease-modifying agents (DMA) including β-interferons (IFNβ) are being used in MS(More)
OBJECTIVE Achillea millefolium (A. millefolium) is widely used as an anti-inflammatory remedy in traditional and herbal medicine. In this study, we investigated the effect of an aqueous extract from A. millefolium on experimental autoimmune encephalomyelitis (EAE) and on the serum cytokine levels in C57BL/6 mice. MATERIALS AND METHODS EAE was induced in(More)
Vascular endothelial growth factor (VEGF) and its receptor kinase insert domain-containing receptor (KDR) pathway trigger the process of angiogenesis as well as inflammation, which contributes to the development and progression of demyelinating lesions in multiple sclerosis. This work is a case–control study comprising of a total of 400 subjects with(More)
J Jo ou ur rn na al l o of f E En nv vi ir ro on nm me en nt ta al l a an nd d O Oc cc cu up pa at ti io on na al l S Sc ci ie en nc ce e available at www.scopemed.org Abstract Aim: Rheumatoid arthritis is a chronic autoimmune inflammatory disorder of flexible joints with unknown etiology, which afflicts 1% of the world's population. The aim of this study(More)
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