Mohammad Ishaq

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BACKGROUND It is known that retinoid receptor function is attenuated during T cell activation, a phenomenon that involves actin remodeling, suggesting that actin modification may play a role in such inhibition. Here we have investigated the role of actin dynamics and the effect of actin cytoskeleton modifying agents on retinoid receptor-mediated(More)
Authors' contributions MI and VN conceived the study. MI wrote the manuscript and carried out IF, and transcription studies. VN evaluated the data and revised the manuscript. LB carried out reporter assays with Nef constructs. MB carried out the gene array experiments. AA-G carried out the reporter assays with Nef constructs and Western blots. XZ, JY, DH,(More)
Authors' contributions MI and VN conceived the study. MI wrote the manuscript and carried out IF, and transcription studies. VN evaluated the data and revised the manuscript. LB carried out reporter assays with Nef constructs. MB carried out the gene array experiments. AA-G carried out the reporter assays with Nef constructs and Western blots. XZ, JY, DH,(More)
We have recently shown that Zap70 is important in retinoid receptor-dependent transactivation in T lymphocytes. We report that Zap70 signaling is also essential in dexamethasone-inducible glucocorticoid receptor (GR)-mediated transactivation in T lymphocytes. Zap70-negative Jurkat T cells and cells reconstituted with inactive Zap70 exhibited attenuated(More)
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