Mohammad Hossein Nasr-Esfahani

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To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely globozoospermia. The two initial descriptions of the DPY19L2 deletion lead to a very different rate of occurrence of this mutation among globospermic patients. In order to better estimate the contribution of DPY19L2 in(More)
OBJECTIVE To review different methods for artificial oocyte activation and its impact on intracytoplasmic sperm injection (ICSI). DESIGN Literature review. SETTING University-based and university-affiliated medical centers. PATIENT(S) None. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) None. RESULT(S) The ICSI procedure improves fertilization(More)
OBJECTIVE To evaluate the relationship between late spermiogenic events, including histone-protamine replacement, acrosome integrity, and sperm morphology, with fertilization rate after intracytoplasmic sperm injection (ICSI). DESIGN Prospective study. SETTING Isfahan Fertility and Infertility Center, Royan Institute, Tehran, Iran. PATIENT(S) Semen(More)
Schwann cells (SCs) can be used to repair both the peripheral and central nervous systems. Therefore, establishment of a procedure to obtain activated, highly proliferative SCs, in an appropriate time for clinical applications, is a prerequisite. Purification is complicated by contamination with fibroblasts which often become the predominant cell type in an(More)
PURPOSE To compare the efficiency of routine sperm selection method with HA-selection procedure for fertilization rate, embryo development, implantation and pregnancy rates as well as evaluating the relationship between HA-binding ability with sperm protamine deficiency and DNA fragmentation. METHODS Semen samples were obtained from the 50 couples(More)
OBJECTIVE To evaluate efficiency of ionomycin on fertilization and cleavage rates, embryo development, and pregnancy rate after intracytoplasmic sperm injection (ICSI) in teratozoospermic patients. DESIGN Laboratory study. SETTING Isfahan fertility and infertility Center, and Royan institute, Tehran, Iran. PATIENT(S) Eighty-seven couples with male(More)
Tissue engineering techniques using a combination of polymeric scaffolds and cells represent a promising approach for nerve regeneration. We fabricated electrospun scaffolds by blending of Poly (3-hydroxybutyrate) (PHB) and Poly (3-hydroxy butyrate-co-3- hydroxyvalerate) (PHBV) in different compositions in order to investigate their potential for the(More)
Artificial oocyte activation (AOA), post intracytoplasmic sperm injection (ICSI) is considered as the only method to overcome failed fertilization post ICSI. However, there is still no prognostic test to foresee failed fertilization and to implement AOA. Therefore, the aim of this study was evaluation of total acrosin activity and its relation to failed(More)
Increased possibility of universality of ooplasmic reprogramming factors resulted in a parallel increased interest to use interspecies somatic cell nuclear transfer (iSCNT) to address basic questions of developmental biology and to improve the feasibility of cell therapy. In this study, the interactions between human somatic cells and ovine oocytes were(More)
The aim of this study was to evaluate the effect of sperm DNA damage and protamine deficiency on fertilization and embryo development post-intracytoplasmic sperm injection (ICSI), and also to assess the effect of protamine deficiency on DNA damage. Semen samples were collected from 28 patients participating in the ICSI programme. Following sperm preparation(More)