Mohammad Goodarzi

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Early diagnostic is one of the most important steps in cancer therapy which helps to design and choose a better therapeutic approach. The finding of biomarkers in various levels including genomics, transcriptomics, and proteomics levels could provide better treatment for various cancers such as chronic lymphocytic leukemia (CLL). The CLL is the one of main(More)
Similarity assessment of complex chromatographic profiles of herbal medicinal products is important as a potential tool for their identification. Mathematical similarity parameters have the advantage to be more reliable than visual similarity evaluations of often subtle differences between the fingerprint profiles. In this paper, different similarity(More)
The activities of a series of HIV reverse transcriptase inhibitor TIBO derivatives were recently modeled by using genetic function approximation (GFA) and artificial neural networks (ANN) on topological, structural, electronic, spatial and physicochemical descriptors. The prediction results were found to be superior to those previously established. In the(More)
Leishmaniasis is a neglected disease transmitted in many tropical and sub-tropical countries, with few studies devoted to its treatment. In this work, the activities of two antileishmanial compound classes were modeled using Dragon descriptors, and multiple linear (MLR) and support vector machines (SVM) as linear and nonlinear regression methods,(More)
The support vector machine (SVM) and partial least square (PLS) methods were used to develop quantitative structure activity relationship (QSAR) models to predict the inhibitory activity of non-peptide HIV-1 protease inhibitors. Genetic algorithm (GA) was employed to select variables that lead to the best-fitted models. A comparison between the obtained(More)
Polybrominated diphenyl ethers (PBDEs) are experimentally indicated to be capable of binding to the cytosolic aryl hydrocarbon receptor (AhR) and show a weak or moderate toxicity. However, little is yet known about the AhR-mediated toxicology. To fully evaluate the structural effects of PBDE ligand on AhR binding affinity and toxicity, quantitative(More)
Micro-grids consist of distributed power generation systems (DGs), distributed energy storage devices (DSs), and loads. Controlling these systems is more difficult than ordinary form of power systems since, in most of them, their energy is provided by renewable energies which have uncertain and varying nature. These fluctuations in the generated power might(More)
In spite of significant progress in anti-HIV-1 therapy, current antiviral chemotherapy still suffers from deleterious side effects and emerging drug resistance. Styrylquinoline derivative compounds have been shown to inhibit IN integration activity in vitro and to block viral replication at non-toxic concentrations. To understand the pharmacophore(More)
Herbal medicines are becoming again more popular in the developed countries because being "natural" and people thus often assume that they are inherently safe. Herbs have also been used worldwide for many centuries in the traditional medicines. The concern of their safety and efficacy has grown since increasing western interest. Herbal materials and their(More)
Stroke is a life-threatening disease that accounts for a considerable burden of mortality in both developing and developed world. Identification of specific biomarkers for stroke and its outcomes can greatly contribute to improved care of patients. MicroRNAs (miRNAs) are known as novel biomarkers that could be used as diagnostic, prognostic, and therapeutic(More)