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OBJECTIVES Poor adherence is one of the biggest obstacles in therapeutic control of high blood pressure. The objectives of this study were (i) to measure adherence to antihypertensive therapy in a representative sample of the hypertensive Pakistani population and (ii) to investigate the factors associated with adherence in the studied population. METHODS(More)
BACKGROUND It is known that retinoid receptor function is attenuated during T cell activation, a phenomenon that involves actin remodeling, suggesting that actin modification may play a role in such inhibition. Here we have investigated the role of actin dynamics and the effect of actin cytoskeleton modifying agents on retinoid receptor-mediated(More)
Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians. In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated(More)
  • Mohammad Kakar, Ishaq, Andrew Kerr, Craig, Khalid, Alan S Collins +9 others
  • 2014
Publishers page: Please note: Changes made as a result of publishing processes such as copy-editing, formatting and page numbers may not be reflected in this version. For the definitive version of this publication, please refer to the published source. You are advised to consult the publisher's version if you wish to cite this paper. This is a PDF file of(More)
INTRODUCTION The simultaneous presence of Takayasu's arteritis and beta thalassemia trait is a rare combination. To the best of our knowledge, this is the first case report on Takayasu's arteritis and beta thalassemia presenting together. CASE PRESENTATION This is a case report of a 23-year-old Asian woman of Pakistani descent who presented with a(More)
BACKGROUND Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of death and disability worldwide. Overall survival after an OHCA has been reported to be poor and limited studies have been conducted in developing countries. We aimed to investigate the rates of survival from OHCA and explore components of the chain of survival in a developing(More)
Authors' contributions MI and VN conceived the study. MI wrote the manuscript and carried out IF, and transcription studies. VN evaluated the data and revised the manuscript. LB carried out reporter assays with Nef constructs. MB carried out the gene array experiments. AA-G carried out the reporter assays with Nef constructs and Western blots. XZ, JY, DH,(More)
Authors' contributions MI and VN conceived the study. MI wrote the manuscript and carried out IF, and transcription studies. VN evaluated the data and revised the manuscript. LB carried out reporter assays with Nef constructs. MB carried out the gene array experiments. AA-G carried out the reporter assays with Nef constructs and Western blots. XZ, JY, DH,(More)
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